Microneedle-based Ocular Drug Delivery Systems - Recent Advances and Challenges

Overview

Journal Beilstein J Nanotechnol

Specialty Biotechnology

Date 2022 Nov 9

PMID 36348935

Authors

Piotr Gadzinski

Anna Froelich

Monika Wojtylko

Antoni Bialek

Julia Krysztofiak

Tomasz Osmalek

Affiliations

Soon will be listed here.

Abstract

Eye diseases and injuries constitute a significant clinical problem worldwide. Safe and effective delivery of drugs to the eye is challenging mostly due to the presence of ocular barriers and clearance mechanisms. In everyday practice, the traditional eye drops, gels and ointments are most often used. Unfortunately, they are usually not well tolerated by patients due to the need for frequent use as well as the discomfort during application. Therefore, novel drug delivery systems with improved biopharmaceutical properties are a subject of ongoing scientific investigations. Due to the developments in microtechnology, in recent years, there has been a remarkable advance in the development of microneedle-based systems as an alternative, non-invasive form for administering drugs to the eye. This review summarizes the latest achievements in the field of obtaining microneedle ocular patches. In the manuscript, the most important manufacturing technologies, microneedle classification, and the research studies related to ophthalmic application of microneedles are presented. Finally, the most important advantages and drawbacks, as well as potential challenges related to the unique anatomy and physiology of the eye are summarized and discussed.

Citing Articles

Revolutionizing Eye Care: Exploring the Potential of Microneedle Drug Delivery.

Rojekar S, Parit S, Gholap A, Manchare A, Nangare S, Hatvate N Pharmaceutics. 2024; 16(11).

PMID: 39598522 PMC: 11597228. DOI: 10.3390/pharmaceutics16111398.

Advancements in Ocular Therapy: A Review of Emerging Drug Delivery Approaches and Pharmaceutical Technologies.

Giri B, Jakka D, Sandoval M, Kulkarni V, Bao Q Pharmaceutics. 2024; 16(10).

PMID: 39458654 PMC: 11511072. DOI: 10.3390/pharmaceutics16101325.

Rapidly Dissolving Trans-scleral Microneedles for Intraocular Delivery of Cyclosporine A.

Alrbyawi H, Annaji M, Fasina O, Palakurthi S, Boddu S, Hassan N AAPS PharmSciTech. 2024; 25(2):28.

PMID: 38302687 DOI: 10.1208/s12249-024-02738-5.

Fabrication Technology of Self-Dissolving Sodium Hyaluronate Gels Ultrafine Microneedles for Medical Applications with UV-Curing Gas-Permeable Mold.

Yamagishi R, Miura S, Yabu K, Ando M, Hachikubo Y, Yokoyama Y Gels. 2024; 10(1).

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Overview of Recent Advances in Nano-Based Ocular Drug Delivery.

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