Sonic Hedgehog-dependent Recruitment of GABAergic Interneurons into the Developing Visual Thalamus

Overview

Journal Elife

Specialty Biology

Date 2022 Nov 7

PMID 36342840

Authors

Rachana Deven Somaiya

Katelyn Stebbins

Ellen C Gingrich

Hehuang Xie

John N Campbell

A Denise R Garcia

Michael A Fox

Affiliations

Soon will be listed here.

Abstract

Axons of retinal ganglion cells (RGCs) play critical roles in the development of inhibitory circuits in visual thalamus. We previously reported that RGC axons signal astrocytes to induce the expression of fibroblast growth factor 15 (FGF15), a motogen required for GABAergic interneuron migration into visual thalamus. However, how retinal axons induce thalamic astrocytes to generate and influence interneuron migration remains unknown. Here, we demonstrate that impairing RGC activity had little impact on interneuron recruitment into mouse visual thalamus. Instead, our data show that retinal-derived sonic hedgehog (SHH) is essential for interneuron recruitment. Specifically, we show that thalamus-projecting RGCs express SHH and thalamic astrocytes generate downstream components of SHH signaling. Deletion of RGC-derived SHH leads to a significant decrease in expression, as well as in the percentage of interneurons recruited into visual thalamus. Overall, our findings identify a morphogen-dependent neuron-astrocyte signaling mechanism essential for the migration of thalamic interneurons.

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