Usefulness of Frailty to Predict Short- and Long-term Outcomes in Patients Who Have Undergone Major Hepatectomy for Perihilar Cholangiocarcinoma

Overview

Journal Ann Gastroenterol Surg

Date 2022 Nov 7

PMID 36338592

Authors

Kiyotaka Hosoda

Akira Shimizu

Koji Kubota

Tsuyoshi Notake

Hitoshi Masuo

Takahiro Yoshizawa

Hiroki Sakai

Hikaru Hayashi

Koya Yasukawa

Yuji Soejima

Affiliations

Soon will be listed here.

Abstract

Aim: The influence of frailty on outcomes after hepatectomy for perihilar cholangiocarcinoma (PHCC) remains unclear. This study aimed to investigate the impact of frailty on the incidence of postoperative complications and survival after major hepatectomy for PHCC.

Methods: A total of 87 patients who had undergone surgery for PHCC between 2007 and 2020 were enrolled in this study. Frailty was scored retrospectively using the Clinical Frailty Scale (CFS). The survival and incidence of postoperative complications were compared based on the degree of frailty, and their risk factors were analyzed.

Results: The overall survival of the CFS score 1-2 group was significantly higher than that of the CFS score 3-7 group ( = .01). The survival benefit was especially observed in stage I or II PHCC. Furthermore, there were significant differences between the CFS score 1-3 group and the CFS score 4-7 group in the incidence of Clavien-Dindo classification grade ≥ IIIa (39.4% vs 70.6%; = .03). Frailty was an independent risk factor for severe postoperative complications (odds ratio, 4.11; 95% confidence interval, 1.18-15.20; = .03) and the incidence of systemic complications ( < .01).

Conclusion: Frailty is a predictive factor for short- and long-term outcomes in patients who have undergone major hepatectomy for PHCC.

Citing Articles

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Frailty Increases Morbidity and Mortality in Patients Undergoing Oncological Liver Resections: A Systematic Review and Meta-analysis.

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PMID: 38856830 PMC: 11413144. DOI: 10.1245/s10434-024-15571-8.

Usefulness of frailty to predict short- and long-term outcomes in patients who have undergone major hepatectomy for perihilar cholangiocarcinoma.

Hosoda K, Shimizu A, Kubota K, Notake T, Masuo H, Yoshizawa T Ann Gastroenterol Surg. 2022; 6(6):833-841.

PMID: 36338592 PMC: 9628246. DOI: 10.1002/ags3.12596.

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