Procalcitonin Measurement in West Nile Virus Neuroinvasive Disease: A First Case Series

Overview

Journal J Assoc Med Microbiol Infect Dis Can

Date 2022 Nov 7

PMID 36337758

Authors

Cheyanne Boehm

Christopher Doig

Justin Z Chen

Wendy I Sligl

Sean M Bagshaw

John Conly

Affiliations

Soon will be listed here.

Abstract

Methods: Daily (days 1-7) serum PCT (bioMérieux) was examined for critically ill patients with sepsis enrolled in a provincial sepsis study. Patients with identified WNV-NID are descriptively analyzed in this case series. PCT values of ≥0.5 ng/mL were suggestive of bacterial infection.

Results: Four patients with WNV-NID were identified. Those with viral infections alone had consistently low PCT values ranging from 0.09 ng/mL to 0.34 ng/mL. Those with documented bacterial co-infections had initially elevated PCT levels that decreased by more than 50% with antimicrobial therapy.

Conclusion: These cases are the first to report serial PCT measurements in confirmed cases of WNV-NID and support a low serum PCT in WNV-NID.

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