Application of Stem Cell in Human Erectile Dysfunction - A Systematic Review

Overview

Journal Res Rep Urol

Publisher Dove Medical Press

Specialty Urology

Date 2022 Nov 2

PMID 36320568

Authors

Safendra Siregar

Aidil Rahman Novesar

Akhmad Mustafa

Affiliations

Soon will be listed here.

Abstract

Introduction: Erectile dysfunction is a health problem that arises from various conditions and causes an impaired quality of life with a significant health burden. Regenerative and stem cell therapies are some of the potential treatments for erectile dysfunction. This study aimed to review the available information in the literature regarding the use of stem cells in the treatment of erectile dysfunction.

Methods: This study is a systematic review conducted based on the PubMed, Google Scholar, Cochrane, and DOAJ databases. Literature searching was conducted in English and included articles from 2000 to 2020.

Results: The result was a total of 318 articles. Following the elimination process, 9 articles remained in the final analysis. The analyzed studies included 164 patients with erectile dysfunction with various medical conditions. Several stem cell types have been used for treating erectile dysfunction, including mesenchymal stem cell, placental matrix-derived stem cell, mesenchymal stem cell-derived exosome, adipose-derived stem cell, bone marrow-derived mononuclear stem cell, and umbilical cord blood stem cell. Generally, stem cell therapy showed a good efficacy and safety profile, although not enough studies on the protocol, dosage, and mechanism of action.

Conclusion: Stem cell therapy has a good therapeutic potential in erectile dysfunction, the available data from the literature could be the base of usage of stem cells in the treatment of erectile dysfunction although need more research for broader usage.

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References

Levy J, Marchand M, Iorio L, Cassini W, Zahalsky M . Determining the Feasibility of Managing Erectile Dysfunction in Humans With Placental-Derived Stem Cells. J Am Osteopath Assoc. 2016; 116(1):e1-5. DOI: 10.7556/jaoa.2016.007. View

Peak T, Anaissie J, Hellstrom W . Current Perspectives on Stem Cell Therapy for Erectile Dysfunction. Sex Med Rev. 2016; 4(3):247-256. DOI: 10.1016/j.sxmr.2016.02.003. View

Bajada S, Mazakova I, Richardson J, Ashammakhi N . Updates on stem cells and their applications in regenerative medicine. J Tissue Eng Regen Med. 2008; 2(4):169-83. DOI: 10.1002/term.83. View

Protogerou V, Chrysikos D, Karampelias V, Spanidis Y, Sara E, Troupis T . Erectile Dysfunction Treatment Using Stem Cells: A Review. Medicines (Basel). 2021; 8(1). PMC: 7825548. DOI: 10.3390/medicines8010002. View

Haahr M, Jensen C, Toyserkani N, Andersen D, Damkier P, Sorensen J . Safety and Potential Effect of a Single Intracavernous Injection of Autologous Adipose-Derived Regenerative Cells in Patients with Erectile Dysfunction Following Radical Prostatectomy: An Open-Label Phase I Clinical Trial. EBioMedicine. 2016; 5:204-10. PMC: 4816754. DOI: 10.1016/j.ebiom.2016.01.024. View

Mobley D, Khera M, Baum N . Recent advances in the treatment of erectile dysfunction. Postgrad Med J. 2017; 93(1105):679-685. DOI: 10.1136/postgradmedj-2016-134073. View

Kumar N, Singh A . Trends of male factor infertility, an important cause of infertility: A review of literature. J Hum Reprod Sci. 2016; 8(4):191-6. PMC: 4691969. DOI: 10.4103/0974-1208.170370. View

Bahk J, Jung J, Han H, Min S, Lee Y . Treatment of diabetic impotence with umbilical cord blood stem cell intracavernosal transplant: preliminary report of 7 cases. Exp Clin Transplant. 2010; 8(2):150-60. View

Matz E, Terlecki R, Zhang Y, Jackson J, Atala A . Stem Cell Therapy for Erectile Dysfunction. Sex Med Rev. 2018; 7(2):321-328. DOI: 10.1016/j.sxmr.2017.12.008. View

10.

Gur S, Abdel-Mageed A, Sikka S, Hellstrom W . Advances in stem cell therapy for erectile dysfunction. Expert Opin Biol Ther. 2018; 18(11):1137-1150. DOI: 10.1080/14712598.2018.1534955. View

11.

Agarwal A, Mulgund A, Hamada A, Chyatte M . A unique view on male infertility around the globe. Reprod Biol Endocrinol. 2015; 13:37. PMC: 4424520. DOI: 10.1186/s12958-015-0032-1. View

12.

Ory J, Saltzman R, Blachman-Braun R, Dadoun S, DiFede D, Premer C . The Effect of Transendocardial Stem Cell Injection on Erectile Function in Men With Cardiomyopathy: Results From the TRIDENT, POSEIDON, and TAC-HFT Trials. J Sex Med. 2020; 17(4):695-701. DOI: 10.1016/j.jsxm.2020.01.003. View

13.

Yiou R, Hamidou L, Birebent B, Bitari D, Le Corvoisier P, Contremoulins I . Intracavernous Injections of Bone Marrow Mononucleated Cells for Postradical Prostatectomy Erectile Dysfunction: Final Results of the INSTIN Clinical Trial. Eur Urol Focus. 2017; 3(6):643-645. DOI: 10.1016/j.euf.2017.06.009. View

14.

Levy J, Marchand M, Iorio L, Zribi G, Zahalsky M . Effects of Stem Cell Treatment in Human Patients With Peyronie Disease. J Am Osteopath Assoc. 2015; 115(10):e8-13. DOI: 10.7556/jaoa.2015.124. View

15.

Lin C, Xin Z, Wang Z, Deng C, Huang Y, Lin G . Stem cell therapy for erectile dysfunction: a critical review. Stem Cells Dev. 2011; 21(3):343-51. PMC: 3272247. DOI: 10.1089/scd.2011.0303. View

16.

Muneer A, Kalsi J, Nazareth I, Arya M . Erectile dysfunction. BMJ. 2014; 348:g129. DOI: 10.1136/bmj.g129. View