Redox Status Response of Physical Exercise Training in Women with Breast Cancer During Trastuzumab Therapy

Overview

Journal Healthcare (Basel)

Specialty Health Services

Date 2022 Oct 27

PMID 36292486

Authors

Katarzyna Hojan

Karolina Gerreth

Danuta Procyk

Krystian Mania

Anna Zalewska

Mateusz Maciejczyk

Affiliations

Soon will be listed here.

Abstract

Aim: The study aimed to analyze the relationship between regular physical activity and the redox status in women with BC during trastuzumab therapy.

Materials And Methods: We observed 50 BC patients during trastuzumab therapy in two groups: one that undertook moderately intensive supervised physical exercises, and a second that performed physical activity according to the recommendations for cancer patients, along with a third (control) group of healthy women.

Results: The antioxidant enzyme and non-enzymatic antioxidant activities were significantly higher in the exercised group compared with the other participants. The concentrations of lipid and protein oxidative damage and nitrosative stress products were significantly higher in both BC groups than in the healthy controls.

Conclusions: Trastuzumab treatment stimulates a redox response in BC patients. The results highlight the oxidative imbalance in parallel with regular physical training in women with BC during trastuzumab therapy. Further studies are needed to analyze different intensities and levels of physical training in women with BC during trastuzumab treatment.

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The impact of physical activity on promoter-specific methylation of genes involved in the redox-status and disease progression: A longitudinal study on post-surgery female breast cancer patients undergoing medical treatment.

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