Levels of Glutathione, Glutathione Reductase and Glutathione S-transferase Activities in Rat Lung and Liver

Overview

Journal Biochim Biophys Acta

Specialties Biochemistry
Biophysics

Date 1979 Jan 4

PMID 760819

Citations 774

Authors

M S Moron

J W Depierre

B Mannervik

Affiliations

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Abstract

Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver have been investigated. After perfusing the lung to remove contaminating blood, this organ was found to have an apparent concentration of glutathione (2mM) which is approx. 20% of that found in the liver. Both organs contain very low levels of glutathione disulfide. Neither phenobarbital nor methylcholanthrene had a significant effect on the levels of reduced glutathione in lung and liver. In addition, the activities of some glutathione-metabolizing enzymes--glutathione reductase and glutathione S-transferase activity assayed with four different substrates--were observed to be 5-to 60-fold lower in lung tissue than in the liver.

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