Real-Time Temperature Rise Estimation During Irreversible Electroporation Treatment Through State-Space Modeling

Overview

Journal Bioengineering (Basel)

Date 2022 Oct 27

PMID 36290467

Authors

Sabrina N Campelo

Edward J Jacobs 4th

Kenneth N Aycock

Rafael V Davalos

Affiliations

Soon will be listed here.

Abstract

To evaluate the feasibility of real-time temperature monitoring during an electroporation-based therapy procedure, a data-driven state-space model was developed. Agar phantoms mimicking low conductivity (LC) and high conductivity (HC) tissues were tested under the influences of high (HV) and low (LV) applied voltages. Real-time changes in impedance, measured by Fourier Analysis SpecTroscopy (FAST) along with the known tissue conductivity and applied voltages, were used to train the model. A theoretical finite element model was used for external validation of the model, producing model fits of 95.8, 88.4, 90.7, and 93.7% at 4 mm and 93.2, 58.9, 90.0, and 90.1% at 10 mm for the HV-HC, LV-LC, HV-LC, and LV-HC groups, respectively. The proposed model suggests that real-time temperature monitoring may be achieved with good accuracy through the use of real-time impedance monitoring.

Citing Articles

Multiscale Thermal Technologies: Exploring Hot and Cold Potentials in Biomedical Applications.

Yu B, Huang H Bioengineering (Basel). 2024; 11(10).

PMID: 39451403 PMC: 11505225. DOI: 10.3390/bioengineering11101028.

Data encryption/decryption and medical image reconstruction based on a sustainable biomemristor designed logic gate circuit.

Lin F, Cheng Y, Li Z, Wang C, Peng W, Cao Z Mater Today Bio. 2024; 29:101257.

PMID: 39381266 PMC: 11459028. DOI: 10.1016/j.mtbio.2024.101257.

References

Schwan H . Electrical properties of tissue and cell suspensions. Adv Biol Med Phys. 1957; 5:147-209. DOI: 10.1016/b978-1-4832-3111-2.50008-0. View

Garcia P, Davalos R, Miklavcic D . A numerical investigation of the electric and thermal cell kill distributions in electroporation-based therapies in tissue. PLoS One. 2014; 9(8):e103083. PMC: 4130512. DOI: 10.1371/journal.pone.0103083. View

Geboers B, Scheffer H, Graybill P, Ruarus A, Nieuwenhuizen S, Puijk R . High-Voltage Electrical Pulses in Oncology: Irreversible Electroporation, Electrochemotherapy, Gene Electrotransfer, Electrofusion, and Electroimmunotherapy. Radiology. 2020; 295(2):254-272. DOI: 10.1148/radiol.2020192190. View

Aycock K, Campelo S, Davalos R . A Comparative Modeling Study of Thermal Mitigation Strategies in Irreversible Electroporation Treatments. J Heat Transfer. 2022; 144(3):031206. PMC: 8823459. DOI: 10.1115/1.4053199. View

Davalos R, Mir I, Rubinsky B . Tissue ablation with irreversible electroporation. Ann Biomed Eng. 2005; 33(2):223-31. DOI: 10.1007/s10439-005-8981-8. View

Dunki-Jacobs E, Philips P, Martin 2nd R . Evaluation of thermal injury to liver, pancreas and kidney during irreversible electroporation in an in vivo experimental model. Br J Surg. 2014; 101(9):1113-21. DOI: 10.1002/bjs.9536. View

Wagstaff P, de Bruin D, van den Bos W, Ingels A, van Gemert M, Zondervan P . Irreversible electroporation of the porcine kidney: Temperature development and distribution. Urol Oncol. 2015; 33(4):168.e1-7. DOI: 10.1016/j.urolonc.2014.11.019. View

Cindric H, Mariappan P, Beyer L, Wiggermann P, Moche M, Miklavcic D . Retrospective Study for Validation and Improvement of Numerical Treatment Planning of Irreversible Electroporation Ablation for Treatment of Liver Tumors. IEEE Trans Biomed Eng. 2021; 68(12):3513-3524. DOI: 10.1109/TBME.2021.3075772. View

Scheffer H, Vogel J, van den Bos W, Neal 2nd R, van Lienden K, Besselink M . The Influence of a Metal Stent on the Distribution of Thermal Energy during Irreversible Electroporation. PLoS One. 2016; 11(2):e0148457. PMC: 4742246. DOI: 10.1371/journal.pone.0148457. View

10.

Mercadal B, Beitel-White N, Aycock K, Castellvi Q, Davalos R, Ivorra A . Dynamics of Cell Death After Conventional IRE and H-FIRE Treatments. Ann Biomed Eng. 2020; 48(5):1451-1462. PMC: 7154019. DOI: 10.1007/s10439-020-02462-8. View

11.

Maor E, Sugrue A, Witt C, Vaidya V, DeSimone C, Asirvatham S . Pulsed electric fields for cardiac ablation and beyond: A state-of-the-art review. Heart Rhythm. 2019; 16(7):1112-1120. DOI: 10.1016/j.hrthm.2019.01.012. View

12.

Faroja M, Ahmed M, Appelbaum L, Ben-David E, Moussa M, Sosna J . Irreversible electroporation ablation: is all the damage nonthermal?. Radiology. 2012; 266(2):462-70. DOI: 10.1148/radiol.12120609. View

13.

Brock R, Beitel-White N, Davalos R, Allen I . Starting a Fire Without Flame: The Induction of Cell Death and Inflammation in Electroporation-Based Tumor Ablation Strategies. Front Oncol. 2020; 10:1235. PMC: 7399335. DOI: 10.3389/fonc.2020.01235. View

14.

Gabriel S, Lau R, Gabriel C . The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz. Phys Med Biol. 1996; 41(11):2251-69. DOI: 10.1088/0031-9155/41/11/002. View

15.

Agnass P, van Veldhuisen E, van Gemert M, van der Geld C, van Lienden K, van Gulik T . Mathematical modeling of the thermal effects of irreversible electroporation for , , and clinical use: a systematic review. Int J Hyperthermia. 2020; 37(1):486-505. DOI: 10.1080/02656736.2020.1753828. View

16.

Weaver J, Smith K, Esser A, Son R, Gowrishankar T . A brief overview of electroporation pulse strength-duration space: a region where additional intracellular effects are expected. Bioelectrochemistry. 2012; 87:236-43. PMC: 3423488. DOI: 10.1016/j.bioelechem.2012.02.007. View

17.

Ivorra A, Rubinsky B . In vivo electrical impedance measurements during and after electroporation of rat liver. Bioelectrochemistry. 2006; 70(2):287-95. DOI: 10.1016/j.bioelechem.2006.10.005. View

18.

Wittkampf F, van Es R, Neven K . Electroporation and its Relevance for Cardiac Catheter Ablation. JACC Clin Electrophysiol. 2018; 4(8):977-986. DOI: 10.1016/j.jacep.2018.06.005. View

19.

Weaver J . Electroporation: a general phenomenon for manipulating cells and tissues. J Cell Biochem. 1993; 51(4):426-35. DOI: 10.1002/jcb.2400510407. View

20.

Arena C, Mahajan R, Rylander M, Davalos R . An experimental and numerical investigation of phase change electrodes for therapeutic irreversible electroporation. J Biomech Eng. 2013; 135(11):111009. DOI: 10.1115/1.4025334. View