Non-coding Antisense Transcripts: Fine Regulation of Gene Expression in Cancer

Overview

Journal Comput Struct Biotechnol J

Specialty Biotechnology

Date 2022 Oct 26

PMID 36284703

Authors

Francisco Santos

Ana Maria Capela

Francisca Mateus

Sandrina Nobrega-Pereira

Bruno Bernardes de Jesus

Affiliations

Soon will be listed here.

Abstract

Natural antisense transcripts (NATs) are coding or non-coding RNA sequences transcribed on the opposite direction from the same genomic locus. NATs are widely distributed throughout the human genome and seem to play crucial roles in physiological and pathological processes, through newly described and targeted mechanisms. NATs represent the intricate complexity of the genome organization and constitute another layer of potential targets in disease. Here, we focus on the interesting and unique role of non-coding NATs in cancer, paying particular attention to those acting as miRNA sponges.

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