Quantitative Experimental Embryology: A Modern Classical Approach

Overview

Journal J Dev Biol

Specialty Biology

Date 2022 Oct 24

PMID 36278549

Authors

Lara Busby

Dillan Saunders

Guillermo Serrano Najera

Benjamin Steventon

Affiliations

Soon will be listed here.

Abstract

Experimental Embryology is often referred to as a classical approach of developmental biology that has been to some extent replaced by the introduction of molecular biology and genetic techniques to the field. Inspired by the combination of this approach with advanced techniques to uncover core principles of neural crest development by the laboratory of Roberto Mayor, we review key quantitative examples of experimental embryology from recent work in a broad range of developmental biology questions. We propose that quantitative experimental embryology offers essential ways to explore the reaction of cells and tissues to targeted cell addition, removal, and confinement. In doing so, it is an essential methodology to uncover principles of development that remain elusive such as pattern regulation, scaling, and self-organisation.

Citing Articles

Intrinsic and extrinsic cues time somite progenitor contribution to the vertebrate primary body axis.

Busby L, Serrano Najera G, Steventon B Elife. 2024; 13.

PMID: 38193440 PMC: 10834026. DOI: 10.7554/eLife.90499.

Gastruloids - a minimalistic model to study complex developmental metabolism.

Dingare C, Steventon B Emerg Top Life Sci. 2023; 7(4):455-464.

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