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Computed Tomography and Angiography in MELAS (mitochondrial Myopathy, Encephalopathy, Lactic Acidosis and Stroke-like Episodes); Report of 3 Cases

Overview
Journal Neuroradiology
Specialties Neurology
Radiology
Date 1987 Jan 1
PMID 3627423
Citations 7
Authors
K Hasuo
S Tamura
K Yasumori
A Uchino
S Goda
S Ishimoto
K Kamikaseda
Y Wakuta
M Kishi
K Masuda
Affiliations
Soon will be listed here.
Abstract

Among mitochondrial encephalomyopathies, MELAS (mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes, Pavlakis et al. 1983) is recognized as a distinct syndrome characterized by generalized convulsions and recurrent stroke-like episodes. The neuroradiological findings of three patients with MELAS are reported here. Retrospective review shows that MELAS should be included in the differential diagnosis of infarct-like lesions of the cerebrum.

Citing Articles

CT and MRI imaging of the brain in MELAS syndrome.

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A novel mutation in the thiamine responsive megaloblastic anaemia gene SLC19A2 in a patient with deficiency of respiratory chain complex I.

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Neuroradiological features of six kindreds with MELAS tRNA(Leu) A2343G point mutation: implications for pathogenesis.

Sue C, Crimmins D, Soo Y, Pamphlett R, Presgrave C, Kotsimbos N J Neurol Neurosurg Psychiatry. 1998; 65(2):233-40.

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Clinical, morphological, biochemical, and neuroradiological features of mitochondrial encephalomyopathies. Presentation of 19 patients.

Lindner A, Hofmann E, Naumann M, Becker G, Reichmann H Mol Cell Biochem. 1997; 174(1-2):297-303.

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A new type of mitochondrial encephalomyopathy with stroke-like episodes due to cytochrome oxidase deficiency.

Maertens P, Richardson R, Bastian F, Williams J, Hommes F J Inherit Metab Dis. 1988; 11 Suppl 2:186-8.

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