Increased Accumulation of N-isopropyl-p-(123I)-iodoamphetamine in Two Cases with Mitochondrial Encephalomyopathy with Lactic Acidosis and Strokelike Episodes (MELAS)

Overview

Journal Neuroradiology

Specialties Neurology
Radiology

Date 1989 Jan 1

PMID 2636890

Citations 1

Authors

K Morita

S Ono

M Fukunaga

T Yasuda

Y Higashi

A Terao

R Morita

Affiliations

Soon will be listed here.

Abstract

We present two cases with mitochondrial encephalopathy with lactic acidosis and strokelike episodes (MELAS), which showed both increased and decreased accumulation of N-isopropyl-p-(123I)-iodoamphetamine (123I-IMP) in single photon emission computed tomography (SPECT). The increased accumulation of the tracer occurred, before low density appeared on conventional computed tomography, suggesting that 123I-IMP SPECT may be useful in pathophysiological study of MELAS.

Citing Articles

Neuroradiological features of six kindreds with MELAS tRNA(Leu) A2343G point mutation: implications for pathogenesis.

Sue C, Crimmins D, Soo Y, Pamphlett R, Presgrave C, Kotsimbos N J Neurol Neurosurg Psychiatry. 1998; 65(2):233-40.

PMID: 9703178 PMC: 2170193. DOI: 10.1136/jnnp.65.2.233.

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