Association Between Irisin and Metabolic Parameters in Nondiabetic, Nonobese Adults: a Meta-analysis

Overview

Journal Diabetol Metab Syndr

Publisher Biomed Central

Specialty Endocrinology

Date 2022 Oct 22

PMID 36271416

Authors

Yan Li

Zhenbin Xu

Affiliations

Soon will be listed here.

Abstract

Background: Irisin has been proposed to have a beneficial influence on the metabolic status of animals and humans. However, the relationship between circulating irisin levels and the risks of metabolic components in humans remains unclear. In the present meta-analysis, we aimed to evaluate the association between circulating irisin and metabolic parameters in nonobese, nondiabetic adults.

Methods: We searched PubMed, Embase, the Cochrane Library, Web of Science and ClinicalTrial.gov using the main search terms and identified original articles published prior to March 7, 2022. Studies that met our inclusion criteria and reported the association between irisin and metabolic parameters were included in our meta-analysis. We used the Newcastle Ottawa scale to assess the quality of the included studies.

Results: A total of 14 studies (711 subjects) in 11 articles were included for qualitative and quantitative synthesis. The pooled results showed that circulating irisin was positively and significantly correlated with fasting blood glucose (r = 0.159), HOMA-IR (r = 0.217) and waist-to-hip ratio (WHR) (r = 0.168). However, no significant association was detected between irisin levels and other metabolic parameters.

Conclusions: Thus, these findings indicated the possible link between irisin levels and part of the metabolic parameters in apparently metabolically normal individuals. However, the regulation of irisin in metabolism in humans remains to be fully elucidated, and well-designed prospective studies will be needed in the future. Trial registration The review protocol was registered in the International Prospective Register of Systematic Reviews (PROSPERO): CRD42022315269.

Citing Articles

Relation of serum irisin levels with adiposity, components of metabolic syndrome and carotid intima media thickness in prepubertal children with obesity: a cross-sectional study.

Herouvi D, Vlachopapadopoulou E, Vakaki M, Gouriotis D, Marmarinos A, Kalpia C Endocrine. 2024; 87(3):1031-1040.

PMID: 39725768 DOI: 10.1007/s12020-024-04139-x.

Association of Serum Irisin Levels with Body Composition, Metabolic Profile, Leptin, and Adiponectin Levels in Lean and Obese Children.

Esin K, Batirel S, Ulfer G, Yigit P, Sanlier N Medicina (Kaunas). 2023; 59(11).

PMID: 38004003 PMC: 10673282. DOI: 10.3390/medicina59111954.

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