RNA M A Methylation in Cancer

Overview

Journal Mol Oncol

Specialties Molecular Biology
Oncology

Date 2022 Oct 19

PMID 36260366

Authors

Zhaotong Wang

Jiawang Zhou

Haisheng Zhang

Lichen Ge

Jiexin Li

Hongsheng Wang

Affiliations

Soon will be listed here.

Abstract

N -methyladenosine (m A) is one of the most abundant internal modifications in eukaryotic messenger RNAs (mRNAs) and non-coding RNAs (ncRNAs). It is a reversible and dynamic RNA modification that has been observed in both internal coding segments and untranslated regions. Studies indicate that m A modifications play important roles in translation, RNA splicing, export, degradation and ncRNA processing control. In this review, we focus on the profiles and biological functions of RNA m A methylation on both mRNAs and ncRNAs. The dynamic modification of m A and its potential roles in cancer development are discussed. Moreover, we discuss the possibility of m A modifications serving as potential biomarkers for cancer diagnosis and targets for therapy.

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