Polymorphisms in the and Genes and Its Association with the Susceptibility to Pulmonary Tuberculosis in a Mongolian Population

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2022 Oct 17

PMID 36249417

Authors

Xiaogang Cui

Tianqi Yuan

Pengyuan Ning

Jie Han

Yue Liu

Jiao Feng

Fan Lian

MingYuan Hao

Li Dong

Jinqi Hao

Li Xing

Changxin Wu

Affiliations

Soon will be listed here.

Abstract

Tuberculosis (TB) remains one of the deadliest infectious diseases in the world. Previous genome-wide association studies suggested that single-nucleotide polymorphisms (SNPs) in some genes could indicate the susceptibility to TB in some populations. Herein, we studied the association of SNPs in the immunity-related genes, i.e., and genes with the susceptibility to TB in a Mongolian population in China. A case-control study was performed with 197 TB patients and 217 healthy controls. Six SNPs in and six SNPs in were selected for genotyping test by second-generation sequencing technique. A SNP in gene (rs722555) was identified to be associated with susceptibility to TB in the Mongolian population ( < 0.05). The T allele of rs722555 in gene was associated with a 36% increase of risk at TB (OR 1.36, 95% CI 1.03-1.81), and the CT+TT genotype of rs722555 was associated with a 74% increase of risk at TB (OR 1.74, 95% CI 1.16-2.60) in the dominant genetic model. None of SNPs in gene tested in this study were significantly associated with TB susceptibility, while some individuals with SNPs (rs10956514, rs4733781, rs2033059, rs12680942, rs1017281, rs1469288, and rs17285138) in the gene tended to have a reduced risk at TB. In conclusion, this study suggested that the rs722555 SNP in gene might be a risk factor for TB in a Mongolian population.

Citing Articles

Identification of common diagnostic genes and molecular pathways in endometriosis and systemic lupus erythematosus by machine learning approach and in vitro experiment.

Yang P, Zhu Y, Miao Y, Wang T, Liu W, Zhang J Int J Med Sci. 2025; 22(1):27-43.

PMID: 39744159 PMC: 11659837. DOI: 10.7150/ijms.101754.

SP110 Could be Used as a Potential Predictive and Therapeutic Biomarker for Oral Cancer.

Xu G, Wang X, Qin L, Gao J, Song G Mol Biotechnol. 2024; .

PMID: 38951481 DOI: 10.1007/s12033-024-01212-8.

References

Hou T, Yang C, Tong C, Zhang H, Xiao J, Li J . Overexpression of ASAP1 is associated with poor prognosis in epithelial ovarian cancer. Int J Clin Exp Pathol. 2014; 7(1):280-7. PMC: 3885483. View

Rubinstein U, Schachter J, Sharon N, Talnir R, Amir J . [Tuberculosis in a pair of twins--the use of molecular biology methods for the detection of the source of infection]. Harefuah. 2007; 146(3):170-2, 248. View

Bellamy R . Susceptibility to mycobacterial infections: the importance of host genetics. Genes Immun. 2003; 4(1):4-11. DOI: 10.1038/sj.gene.6363915. View

Abhimanyu , Jha P, Jain A, Arora K, Bose M . Genetic association study suggests a role for SP110 variants in lymph node tuberculosis but not pulmonary tuberculosis in north Indians. Hum Immunol. 2011; 72(7):576-80. DOI: 10.1016/j.humimm.2011.03.014. View

Thye T, Browne E, Chinbuah M, Gyapong J, Osei I, Owusu-Dabo E . No associations of human pulmonary tuberculosis with Sp110 variants. J Med Genet. 2006; 43(7):e32. PMC: 2564561. DOI: 10.1136/jmg.2005.037960. View

Zhou Y, Tan C, Mo Z, Gao Q, He D, Li J . Polymorphisms in the and Gene and Susceptibility to Pulmonary and Spinal Tuberculosis among Southern Chinese Population. Dis Markers. 2018; 2017:4590235. PMC: 5752994. DOI: 10.1155/2017/4590235. View

Curtis J, Luo Y, Zenner H, Cuchet-Lourenco D, Wu C, Lo K . Susceptibility to tuberculosis is associated with variants in the ASAP1 gene encoding a regulator of dendritic cell migration. Nat Genet. 2015; 47(5):523-527. PMC: 4414475. DOI: 10.1038/ng.3248. View

Cong J, Li G, Zhou D, Tao Y, Xiong Y . [Study on relation between Sp110 gene polymorphism and tuberculosis genetic susceptibility of Chongqing Han People]. Wei Sheng Yan Jiu. 2010; 39(5):540-4. View

Gasilina A, Vitali T, Luo R, Jian X, Randazzo P . The ArfGAP ASAP1 Controls Actin Stress Fiber Organization via Its N-BAR Domain. iScience. 2019; 22:166-180. PMC: 6889188. DOI: 10.1016/j.isci.2019.11.015. View

10.

Cai L, Deng S, Liang L, Pan H, Zhou J, Wang M . Identification of genetic associations of SP110/MYBBP1A/RELA with pulmonary tuberculosis in the Chinese Han population. Hum Genet. 2012; 132(3):265-73. DOI: 10.1007/s00439-012-1244-5. View

11.

Onodera Y, Hashimoto S, Hashimoto A, Morishige M, Mazaki Y, Yamada A . Expression of AMAP1, an ArfGAP, provides novel targets to inhibit breast cancer invasive activities. EMBO J. 2005; 24(5):963-73. PMC: 554134. DOI: 10.1038/sj.emboj.7600588. View

12.

Inoue H, Ha V, Prekeris R, Randazzo P . Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome. Mol Biol Cell. 2008; 19(10):4224-37. PMC: 2555923. DOI: 10.1091/mbc.e08-03-0290. View

13.

Sabe H, Hashimoto S, Morishige M, Ogawa E, Hashimoto A, Nam J . The EGFR-GEP100-Arf6-AMAP1 signaling pathway specific to breast cancer invasion and metastasis. Traffic. 2009; 10(8):982-93. PMC: 2721971. DOI: 10.1111/j.1600-0854.2009.00917.x. View

14.

Tanna C, Goss L, Ludwig C, Chen P . Arf GAPs as Regulators of the Actin Cytoskeleton-An Update. Int J Mol Sci. 2019; 20(2). PMC: 6358971. DOI: 10.3390/ijms20020442. View

15.

Chang S, Chen M, Lee M, Liang Y, Lu T, Wang J . Polymorphisms Are Genetic Markers for Vulnerability to Latent and Active Tuberculosis Infection in Taiwan. Dis Markers. 2019; 2018:4687380. PMC: 6304864. DOI: 10.1155/2018/4687380. View

16.

Szeszko J, Healy B, Stevens H, Balabanova Y, Drobniewski F, Todd J . Resequencing and association analysis of the SP110 gene in adult pulmonary tuberculosis. Hum Genet. 2006; 121(2):155-60. DOI: 10.1007/s00439-006-0293-z. View

17.

Wu Y, Guo Z, Yao K, Miao Y, Liang S, Liu F . The Transcriptional Foundations of Sp110-mediated Macrophage (RAW264.7) Resistance to Mycobacterium tuberculosis H37Ra. Sci Rep. 2016; 6:22041. PMC: 4766572. DOI: 10.1038/srep22041. View

18.

Zembrzuski V, Basta P, Callegari-Jacques S, Santos R, Coimbra C, Salzano F . Cytokine genes are associated with tuberculin skin test response in a native Brazilian population. Tuberculosis (Edinb). 2009; 90(1):44-9. DOI: 10.1016/j.tube.2009.11.002. View

19.

Jiang S, Li L, Yue J, Chen W, Yang C, Wan C . The effects of SP110's associated genes on fresh cavitary pulmonary tuberculosis in Han Chinese population. Clin Exp Med. 2015; 16(2):219-25. DOI: 10.1007/s10238-015-0339-4. View

20.

Fox G, Sy D, Nhung N, Yu B, Ellis M, Van Hung N . Polymorphisms of SP110 are associated with both pulmonary and extra-pulmonary tuberculosis among the Vietnamese. PLoS One. 2014; 9(7):e99496. PMC: 4090157. DOI: 10.1371/journal.pone.0099496. View