Polymorphisms in the and Gene and Susceptibility to Pulmonary and Spinal Tuberculosis Among Southern Chinese Population

Overview

Journal Dis Markers

Publisher Wiley

Specialty Biochemistry

Date 2018 Feb 13

PMID 29430075

Citations 8

Authors

Ying Zhou

Chun-Yan Tan

Zhi-Jiang Mo

Qi-Le Gao

Dan He

Jiong Li

Rong-Fu Huang

Yan-Bing Li

Chao-Feng Guo

Qiang Guo

Long-Jie Wang

Guan-Teng Yang

Hong-Qi Zhang

Affiliations

Soon will be listed here.

Abstract

Objective: To investigate the association of single-nucleotide polymorphisms (SNPs) in gene and gene among pulmonary TB (PTB) and spinal TB (STB) patients.

Methods: In a total of 190 PTB patients, 183 STB patients were enrolled as the case group and 362 healthy individuals at the same geographical region as the control group. The SNPs (rs722555 and rs1135791) and the promoter -308G>A (rs1800629) and -238G>A (rs361525) polymorphisms in were genotyped. - -238G>A polymorphism was involved in susceptibility to STB, but not to PTB. The - -238 A allele was a protective factor against STB (A versus G: OR [95% CI] = 0.331 [0.113-0.972], = 0.044). Furthermore, the presence of the -238 A allele was considered a trend to decrease the risk of STB (AG versus GG: = 0.062, OR [95% CI] = 0.352 [0.118-1.053]; AA + AG versus GG: = 0.050, OR [95CI%] = 0.335 [0.113-0.999]). However, SNPs (rs722555 and rs1135791) and -308G>A (rs1800629) showed no association with PTB and STB in all genetic models.

Conclusion: The -238 A allele appeared a protective effect against STB, whereas the SNPs (rs722555 and rs1135791) and -308G>A (rs1800629) showed no association with susceptibility to PTB and STB patients in southern China.

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