MiRNA Effects on Gut Homeostasis: Therapeutic Implications for Inflammatory Bowel Disease

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2022 Oct 11

PMID 36220689

Authors

Shivnarayan Dhuppar

Gopal Murugaiyan

Affiliations

Soon will be listed here.

Abstract

Inflammatory bowel disease (IBD) spans a range of chronic conditions affecting the gastrointestinal (GI) tract, which are marked by intermittent flare-ups and remissions. IBD results from microbial dysbiosis or a defective mucosal barrier in the gut that triggers an inappropriate immune response in a genetically susceptible person, altering the immune-microbiome axis. In this review, we discuss the regulatory roles of miRNAs, small noncoding RNAs with gene regulatory functions, in the stability and maintenance of the gut immune-microbiome axis, and detail the challenges and recent advances in the use of miRNAs as putative therapeutic agents for treating IBD.

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