The Neuronal Growth-associated Protein GAP-43 (B-50, F1): Neuronal Specificity, Developmental Regulation and Regional Distribution of the Human and Rat MRNAs

Overview

Journal Brain Res

Specialty Neurology

Date 1987 Jul 1

PMID 3620911

Citations 25

Authors

R L Neve

N I Perrone-Bizzozero

S Finklestein

H Zwiers

E Bird

D M Kurnit

L I Benowitz

Affiliations

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Abstract

The protein that has been designated as GAP-43, B-50, F1 or pp46 is associated with the growth and modulation of neuronal connections. cDNA clones for the rat and human genes were isolated and used to demonstrate that the messenger RNA for the protein is expressed only in neurons, that its overall level is highest in the developing brain, and that in the adult human brain levels of the mRNA are highest in the associative neocortex.

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