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L I Benowitz

Explore the profile of L I Benowitz including associated specialties, affiliations and a list of published articles. Areas
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Articles 84
Citations 2032
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Recent Articles
1.
Perrone-Bizzozero N, Neve R, Irwin N, Lewis S, Fischer I, Benowitz L
Mol Cell Neurosci . 2009 Nov; 2(5):402-9. PMID: 19912825
The expression of GAP-43 is a well-characterized correlate of the growth and reorganization of neural connections. Although the expression of this protein is known to depend on the levels of...
2.
Cui Q, Yin Y, Benowitz L
Neuroscience . 2008 Aug; 158(3):1039-48. PMID: 18708126
Following injury to the nervous system, the activation of macrophages, microglia, and T-cells profoundly affects the ability of neurons to survive and to regenerate damaged axons. The primary visual pathway...
3.
Irwin N, Li Y, OToole J, Benowitz L
Proc Natl Acad Sci U S A . 2006 Nov; 103(48):18320-5. PMID: 17114295
The growth of axons is fundamental to the development and repair of brain circuitry. We show here that Mst3b, a neuron-specific homolog of the yeast kinase Ste20, is critical for...
4.
Piantino J, Burdick J, Goldberg D, Langer R, Benowitz L
Exp Neurol . 2006 Jun; 201(2):359-67. PMID: 16764857
The failure of long descending pathways to regenerate after spinal cord injury (SCI) is generally attributed to inhibitory proteins associated with the glial scar and myelin, or to the loss...
5.
Benowitz L, Goldberg D, Irwin N
Restor Neurol Neurosci . 2002 Jun; 19(1-2):41-9. PMID: 12082228
Axon growth is characterized by a distinctive program of gene expression. We present evidence here that this program is regulated through a purine-sensitive mechanism, and that it can be re-activated...
6.
Petrausch B, Tabibiazar R, Roser T, Jing Y, Goldman D, Stuermer C, et al.
J Neurosci . 2000 Oct; 20(21):8031-41. PMID: 11050124
In lower vertebrates, retinal ganglion cells (RGCs) can regenerate their axons and reestablish functional connections after optic nerve injury. We show here that in goldfish RGCs, the effects of several...
7.
Leon S, Yin Y, Nguyen J, Irwin N, Benowitz L
J Neurosci . 2000 Jun; 20(12):4615-26. PMID: 10844031
In mature mammals, retinal ganglion cells (RGCs) are unable to regenerate their axons after optic nerve injury, and they soon undergo apoptotic cell death. However, a small puncture wound to...
8.
Kim H, Pomeroy S, Whoriskey W, Pawlitzky I, Benowitz L, Sicinski P, et al.
Neuron . 2000 Jun; 26(2):405-16. PMID: 10839359
Sciatic nerve axons in cyclin D1 knockout mice develop normally, become properly ensheathed by Schwann cells, and appear to function normally. However, in the Wallerian degeneration model of nerve injury,...
9.
Benowitz L, Goldberg D, Madsen J, Soni D, Irwin N
Proc Natl Acad Sci U S A . 1999 Nov; 96(23):13486-90. PMID: 10557347
The purine nucleoside inosine has been shown to induce axon outgrowth from primary neurons in culture through a direct intracellular mechanism. For this study, we investigated the effects of inosine...
10.
Jo S, Wang E, Benowitz L
Neuroscience . 1999 Mar; 89(2):579-91. PMID: 10077337
Although mature mammalian retinal ganglion cells normally fail to regrow injured axons, exposure to the molecular environment of the peripheral nervous system stimulates regenerative growth. The present study used dissociated...