Elevated α-hydroxybutyrate Dehydrogenase is Associated with In-hospital Mortality in Non-ischemic Dilated Cardiomyopathy

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2022 Oct 7

PMID 36204589

Authors

Xinyi Li

Wenfei He

Xiaonan Zhang

Fen Shu

Yaoxin Liu

Ning Tan

Lei Jiang

Affiliations

Soon will be listed here.

Abstract

Background: Previous Study Found That Implantation of a Cardioverter-Defibrillator Likely Caused a Worse Prognosis in Older Patients With non-Ischemic Systolic Heart Failure. This Suggests That More Precise Risk Stratification Is Needed in Elderly Patients. We Conducted a Retrospective Study to Evaluate the Association of α-Hydroxybutyrate Dehydrogenase (α-HBDH) With Mortality During Hospitalization in Elderly Patients With non-Ischemic Dilated Cardiomyopathy (NIDCM).

Methods: 1,019 Elderly Patients (age ≥60 Years) Diagnosed With NIDCM Were Retrospectively Enrolled From January 2010 to December 2019. Univariate and Multivariate Analyses Were Showed to Explore the Relationship Between α-HBDH and in- Hospital Death.

Results: Patients in elevated α-HBDH group (>182 U/L) had a longer hospital stays and higher in-hospital mortality. Univariate logistics regression analysis showed that elevated α-HBDH was significantly related to mortality (OR: 7.004, 95% CI: 3.583-13.693, < 0.001). Receiver operator characteristic (ROC) curve analysis reflected that α-HBDH levels had excellent predictive power for in-hospital death (AUC = 0.810, 95% CI: 0.745-0.876, < 0.001). After adjustment of age, serum creatine, albumin and LVEF, multivariate regression analysis validated the association of elevated α-HBDH with increased risk of in-hospital death ( < 0.05).

Conclusions: Elevated α-HBDH level is significantly related to in-hospital mortality in older patients with NIDCM.

Citing Articles

Serum mAST/ALT ratio had high predictive value for adverse outcome of severe fever with thrombocytopenia syndrome with severe condition.

Wang L, Liu Y, Qu R, Zou Z BMC Infect Dis. 2023; 23(1):168.

PMID: 36932323 PMC: 10022549. DOI: 10.1186/s12879-023-08121-2.

Relationship between serum chloride and prognosis in non-ischaemic dilated cardiomyopathy: a large retrospective cohort study.

Li X, Zhang X, Liu Y, Shu F, Shao S, Tan N BMJ Open. 2022; 12(12):e067061.

PMID: 36535716 PMC: 9764625. DOI: 10.1136/bmjopen-2022-067061.

References

. Dilated cardiomyopathy. Nat Rev Dis Primers. 2019; 5(1):33. DOI: 10.1038/s41572-019-0088-x. View

Lakdawala N, Winterfield J, Funke B . Dilated cardiomyopathy. Circ Arrhythm Electrophysiol. 2012; 6(1):228-37. PMC: 3603701. DOI: 10.1161/CIRCEP.111.962050. View

Potter E, Marwick T . Assessment of Left Ventricular Function by Echocardiography: The Case for Routinely Adding Global Longitudinal Strain to Ejection Fraction. JACC Cardiovasc Imaging. 2018; 11(2 Pt 1):260-274. DOI: 10.1016/j.jcmg.2017.11.017. View

Feng Y, Cai L, Hong W, Zhang C, Tan N, Wang M . Rewiring of 3D Chromatin Topology Orchestrates Transcriptional Reprogramming and the Development of Human Dilated Cardiomyopathy. Circulation. 2022; 145(22):1663-1683. PMC: 9251830. DOI: 10.1161/CIRCULATIONAHA.121.055781. View

Schonberger J, Seidman C . Many roads lead to a broken heart: the genetics of dilated cardiomyopathy. Am J Hum Genet. 2001; 69(2):249-60. PMC: 1235300. DOI: 10.1086/321978. View

Fairweather D, Cooper Jr L, Blauwet L . Sex and gender differences in myocarditis and dilated cardiomyopathy. Curr Probl Cardiol. 2012; 38(1):7-46. PMC: 4136454. DOI: 10.1016/j.cpcardiol.2012.07.003. View

Chen Y, Duan C, Liu F, Shen S, Chen P, Bin J . Impact of etiology on the outcomes in heart failure patients treated with cardiac resynchronization therapy: a meta-analysis. PLoS One. 2014; 9(4):e94614. PMC: 3986107. DOI: 10.1371/journal.pone.0094614. View

Curtis A, Khan H . Refining the Approach to Risk Stratification in Patients With Dilated Cardiomyopathy. J Am Coll Cardiol. 2021; 77(23):2906-2908. DOI: 10.1016/j.jacc.2021.04.031. View

Merlo M, Cannata A, Gobbo M, Stolfo D, Elliott P, Sinagra G . Evolving concepts in dilated cardiomyopathy. Eur J Heart Fail. 2017; 20(2):228-239. DOI: 10.1002/ejhf.1103. View

10.

Liu Z, Li J, Li M, Chen S, Gao R, Zeng G . Elevated α-hydroxybutyrate dehydrogenase as an independent prognostic factor for mortality in hospitalized patients with COVID-19. ESC Heart Fail. 2020; 8(1):644-651. PMC: 7835619. DOI: 10.1002/ehf2.13151. View

11.

Pinto Y, Elliott P, Arbustini E, Adler Y, Anastasakis A, Bohm M . Proposal for a revised definition of dilated cardiomyopathy, hypokinetic non-dilated cardiomyopathy, and its implications for clinical practice: a position statement of the ESC working group on myocardial and pericardial diseases. Eur Heart J. 2016; 37(23):1850-8. DOI: 10.1093/eurheartj/ehv727. View

12.

Roura S, Bayes-Genis A . Vascular dysfunction in idiopathic dilated cardiomyopathy. Nat Rev Cardiol. 2009; 6(9):590-8. DOI: 10.1038/nrcardio.2009.130. View

13.

Dilaveris P, Antoniou C, Gatzoulis K . Arrhythmic risk stratification in non-ischemic dilated cardiomyopathy: Where do we stand after DANISH?. Trends Cardiovasc Med. 2017; 27(8):542-555. DOI: 10.1016/j.tcm.2017.06.003. View

14.

Reichart D, Magnussen C, Zeller T, Blankenberg S . Dilated cardiomyopathy: from epidemiologic to genetic phenotypes: A translational review of current literature. J Intern Med. 2019; 286(4):362-372. DOI: 10.1111/joim.12944. View

15.

Zhang Z, Pereira S, Luo M, Matheson E . Evaluation of Blood Biomarkers Associated with Risk of Malnutrition in Older Adults: A Systematic Review and Meta-Analysis. Nutrients. 2017; 9(8). PMC: 5579622. DOI: 10.3390/nu9080829. View

16.

Lee S, Koppensteiner R, Kopp C, Gremmel T . α-Hydroxybutyrate dehydrogenase is associated with atherothrombotic events following infrainguinal angioplasty and stenting. Sci Rep. 2019; 9(1):18200. PMC: 6890648. DOI: 10.1038/s41598-019-54899-0. View

17.

Barison A, Grigoratos C, Todiere G, Aquaro G . Myocardial interstitial remodelling in non-ischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance. Heart Fail Rev. 2015; 20(6):731-49. DOI: 10.1007/s10741-015-9509-4. View

18.

Kadish A, Dyer A, Daubert J, Quigg R, Mark Estes N, Anderson K . Prophylactic defibrillator implantation in patients with nonischemic dilated cardiomyopathy. N Engl J Med. 2004; 350(21):2151-8. DOI: 10.1056/NEJMoa033088. View

19.

Kober L, Thune J, Nielsen J, Haarbo J, Videbaek L, Korup E . Defibrillator Implantation in Patients with Nonischemic Systolic Heart Failure. N Engl J Med. 2016; 375(13):1221-30. DOI: 10.1056/NEJMoa1608029. View

20.

Kemp M, Donovan J, Higham H, Hooper J . Biochemical markers of myocardial injury. Br J Anaesth. 2004; 93(1):63-73. DOI: 10.1093/bja/aeh148. View