Vascular Dysfunction in Idiopathic Dilated Cardiomyopathy

Overview

Journal Nat Rev Cardiol

Specialty Cardiology & Vascular Diseases

Date 2009 Jul 29

PMID 19636323

Citations 33

Authors

Santiago Roura

Antoni Bayes-Genis

Affiliations

Soon will be listed here.

Abstract

Idiopathic dilated cardiomyopathy (IDCM) is defined as myocardial dilatation and dysfunction in the absence of overt coronary heart disease. Myocardial injury and genetic or environmental factors can lead to the development of IDCM, which was historically characterized by marked abnormalities in the function and integrity of cardiomyocytes. However, cardiac endothelial dysfunction has also been shown to be associated with progression and poor prognosis of IDCM. Moreover, marked vascular derangements and impaired vasculogenic and angiogenic responses have been reported in patients with IDCM. On the basis of these data we re-examine IDCM pathophysiology as a downstream complication of vascular derangements that contribute to myocyte damage. Animal models closely resembling the marked vascular alterations found in patients with IDCM will be of paramount importance for further enhancing our comprehension of disease progression and for testing new drugs and stem-cell or gene-based therapies.

Citing Articles

Association between coronary microvascular dysfunction and exercise capacity in dilated cardiomyopathy.

Dattani A, Marrow B, Gulsin G, Yeo J, Puranik A, Brady E J Cardiovasc Magn Reson. 2024; 26(2):101108.

PMID: 39426603 PMC: 11647499. DOI: 10.1016/j.jocmr.2024.101108.

Integrating Prime Editing and Cellular Reprogramming as Novel Strategies for Genetic Cardiac Disease Modeling and Treatment.

Yao B, Lei Z, Goncalves M, Sluijter J Curr Cardiol Rep. 2024; 26(11):1197-1208.

PMID: 39259489 PMC: 11538137. DOI: 10.1007/s11886-024-02118-2.

Precision therapy in dilated cardiomyopathy: Pipedream or paradigm shift?.

Javed S, Halliday B Camb Prism Precis Med. 2024; 1:e34.

PMID: 38550947 PMC: 10953759. DOI: 10.1017/pcm.2023.24.

The predictive value of coronary microvascular dysfunction for left ventricular reverse remodelling in dilated cardiomyopathy.

Kan A, Leng Y, Li S, Lin F, Fang Q, Tao X Front Cardiovasc Med. 2023; 10:1301509.

PMID: 38111885 PMC: 10726051. DOI: 10.3389/fcvm.2023.1301509.

Insulin-like growth factor binding protein 2: a core biomarker of left ventricular dysfunction in dilated cardiomyopathy.

Yu W, Gao H, Hu T, Tan X, Liu Y, Liu H Hereditas. 2023; 160(1):36.

PMID: 37904201 PMC: 10617082. DOI: 10.1186/s41065-023-00298-5.

References

Maron B, Towbin J, Thiene G, Antzelevitch C, Corrado D, Arnett D . Contemporary definitions and classification of the cardiomyopathies: an American Heart Association Scientific Statement from the Council on Clinical Cardiology, Heart Failure and Transplantation Committee; Quality of Care and Outcomes Research and.... Circulation. 2006; 113(14):1807-16. DOI: 10.1161/CIRCULATIONAHA.106.174287. View

Perrot A, Dietz R, Osterziel K . Is there a common genetic basis for all familial cardiomyopathies?. Eur J Heart Fail. 2006; 9(1):4-6. DOI: 10.1016/j.ejheart.2006.04.010. View

Parodi O, De Maria R, Oltrona L, Testa R, Sambuceti G, Roghi A . Myocardial blood flow distribution in patients with ischemic heart disease or dilated cardiomyopathy undergoing heart transplantation. Circulation. 1993; 88(2):509-22. DOI: 10.1161/01.cir.88.2.509. View

Zhou Y, Li X, Zhang H, Yao W, Tong M, Xu Q . Decreased small arterial compliance with increased serum vascular endothelial growth factor-A and circulating endothelial progenitor cell in dilated cardiomyopathy. Chin Med J (Engl). 2008; 121(4):316-20. View

Hou X, Son J, Wang Y, Ru Y, Lian Q, Majiti W . Granulocyte colony-stimulating factor reduces cardiomyocyte apoptosis and improves cardiac function in adriamycin-induced cardiomyopathy in rats. Cardiovasc Drugs Ther. 2006; 20(2):85-91. DOI: 10.1007/s10557-006-7652-9. View

Assmus B, Urbich C, Aicher A, Hofmann W, Haendeler J, Rossig L . HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res. 2003; 92(9):1049-55. DOI: 10.1161/01.RES.0000070067.64040.7C. View

Schafer R, Abraham D, Paulus P, Blumer R, Grimm M, Wojta J . Impaired VE-cadherin/beta-catenin expression mediates endothelial cell degeneration in dilated cardiomyopathy. Circulation. 2003; 108(13):1585-91. DOI: 10.1161/01.CIR.0000091085.12422.19. View

Bendig G, Grimmler M, Huttner I, Wessels G, Dahme T, Just S . Integrin-linked kinase, a novel component of the cardiac mechanical stretch sensor, controls contractility in the zebrafish heart. Genes Dev. 2006; 20(17):2361-72. PMC: 1560411. DOI: 10.1101/gad.1448306. View

Ceradini D, Kulkarni A, Callaghan M, Tepper O, Bastidas N, Kleinman M . Progenitor cell trafficking is regulated by hypoxic gradients through HIF-1 induction of SDF-1. Nat Med. 2004; 10(8):858-64. DOI: 10.1038/nm1075. View

10.

Wang J, Hoshijima M, Lam J, Zhou Z, Jokiel A, Dalton N . Cardiomyopathy associated with microcirculation dysfunction in laminin alpha4 chain-deficient mice. J Biol Chem. 2005; 281(1):213-20. DOI: 10.1074/jbc.M505061200. View

11.

Nishimura H, Okazaki T, Tanaka Y, Nakatani K, Hara M, Matsumori A . Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science. 2001; 291(5502):319-22. DOI: 10.1126/science.291.5502.319. View

12.

Dodge Jr J, Brown B, Bolson E, DODGE H . Lumen diameter of normal human coronary arteries. Influence of age, sex, anatomic variation, and left ventricular hypertrophy or dilation. Circulation. 1992; 86(1):232-46. DOI: 10.1161/01.cir.86.1.232. View

13.

Quyyumi A . Circulating endothelial progenitor cells as novel biological determinants of vascular function and risk. Can J Cardiol. 2004; 20 Suppl B:44B-48B. View

14.

Urbich C, Dimmeler S . Risk factors for coronary artery disease, circulating endothelial progenitor cells, and the role of HMG-CoA reductase inhibitors. Kidney Int. 2005; 67(5):1672-6. DOI: 10.1111/j.1523-1755.2005.00261.x. View

15.

Gilbert E, Anderson J, Deitchman D, Yanowitz F, OConnell J, Renlund D . Long-term beta-blocker vasodilator therapy improves cardiac function in idiopathic dilated cardiomyopathy: a double-blind, randomized study of bucindolol versus placebo. Am J Med. 1990; 88(3):223-9. DOI: 10.1016/0002-9343(90)90146-5. View

16.

Hill J, Zalos G, Halcox J, Schenke W, Waclawiw M, Quyyumi A . Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med. 2003; 348(7):593-600. DOI: 10.1056/NEJMoa022287. View

17.

Neu N, Rose N, Beisel K, Herskowitz A, Craig S . Cardiac myosin induces myocarditis in genetically predisposed mice. J Immunol. 1987; 139(11):3630-6. View

18.

Baboonian C, Davies M, BOOTH J, McKenna W . Coxsackie B viruses and human heart disease. Curr Top Microbiol Immunol. 1997; 223:31-52. DOI: 10.1007/978-3-642-60687-8_3. View

19.

Richardson P, McKenna W, Bristow M, Maisch B, MAUTNER B, OConnell J . Report of the 1995 World Health Organization/International Society and Federation of Cardiology Task Force on the Definition and Classification of cardiomyopathies. Circulation. 1996; 93(5):841-2. DOI: 10.1161/01.cir.93.5.841. View

20.

Urbich C, Dimmeler S . Endothelial progenitor cells functional characterization. Trends Cardiovasc Med. 2004; 14(8):318-22. DOI: 10.1016/j.tcm.2004.10.001. View