Folic Acid Ameliorates the Declining Quality of Sodium Fluoride-Exposed Mouse Oocytes Through the / Pathway

Overview

Journal Aging Dis

Specialty Geriatrics

Date 2022 Oct 3

PMID 36186127

Authors

Xiaoyuan Lin

Beibei Fu

Yan Xiong

Shiyao Xu

Jin Liu

Mohamed Y Zaky

Dan Qiu

Haibo Wu

Affiliations

Soon will be listed here.

Abstract

Excessive sodium fluoride (NaF) intake interferes with reproductive function in humans and animals; however, strategies to prevent these effects are still underexplored. Here, we showed that and supplementation of folic acid (FA) efficaciously improved the quality of NaF-exposed oocytes. FA supplementation not only increased ovulation of oocytes from NaF-treated mice but also enhanced oocyte meiotic competency and fertilization ability by restoring the spindle/chromosome structure. Moreover, FA supplementation could exert a beneficial effect on NaF- exposed oocytes by restoring mitochondrial function, eliminating reactive oxygen species accumulation to suppress apoptosis. We also found that FA supplementation restored the defective phenotypes in oocytes through a /-dependent mechanism. Inhibition of with EX527 abolished the FA-mediated improvement in NaF-exposed oocyte quality. Collectively, our data indicated that FA supplementation is a feasible approach to protect oocytes from NaF-related deterioration.

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