Reinfection and Reactivation of SARS-CoV-2

Overview

Journal Future Virol

Specialty Microbiology

Date 2022 Sep 30

PMID 36176508

Authors

Razieh Dowran

Amirmasoud Rayati Damavandi

Talat Mokhtari Azad

Affiliations

Soon will be listed here.

Abstract

As the cases of SARS-CoV-2 infection escalates, the essence of in-depth knowledge around acquired immunity and emergence of reinfection and reactivation have to be captured. While being a rare phenomenon, reinfection occurs as the result of diminishing protection conferred by antibodies, especially IgG. Reactivation is more concerned with the role of various elements including shedding lingering viral RNA for a prolonged time and incomplete resolution of infection along with the insight of dormant viral exosomes' role. The concept of testing positive after two consecutive negative results requires proper discrimination of reinfection from reactivation. In this review, we summarized the current evidence for possible mechanisms leading to viral reactivation or test re-positivity. We also pointed out risk factors associated with both reinfection and reactivation.

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