Oxygen As an Essential Medicine

Overview

Journal Crit Care Clin

Specialty Critical Care

Date 2022 Sep 26

PMID 36162911

Authors

Matthew F Mart

Cornelius Sendagire

Eugene Wesley Ely

Elisabeth D Riviello

Theogene Twagirumugabe

Affiliations

Soon will be listed here.

Abstract

Supplemental oxygen is an essential medication in critical care. The optimal oxygen dose delivery system remains unclear, however. The "dose" and "delivery" of oxygen carry significant importance for resource-limited settings, such as low- and middle-income countries (LMICs). Regrettably, LMICS often experience significant inequities in oxygen supply and demand, with major impacts on preventable mortality. These inequities have become particularly prominent during the global COVID-19 pandemic, highlighting the need for additional investment and research into the best methods to utilize supplemental oxygen and ensure stable access to medical oxygen.

Citing Articles

Managing Patients With COVID-19 in Armenia Using a Remote Monitoring System: Descriptive Study.

Musheghyan L, Harutyunyan N, Sikder A, Reid M, Zhao D, Lulejian A JMIR Public Health Surveill. 2024; 10:e57703.

PMID: 39348686 PMC: 11474135. DOI: 10.2196/57703.

Closing gaps in the oxygen supply chain in nations with limited resources.

Humura F, Uwizeyimana T, Kabayundo J, Rucogoza E Pan Afr Med J. 2024; 48:55.

PMID: 39315065 PMC: 11419572. DOI: 10.11604/pamj.2024.48.55.43770.

Challenges for a broad international implementation of the current severe community-acquired pneumonia guidelines.

Salluh J, Povoa P, Beane A, Kalil A, Sendagire C, Sweeney D Intensive Care Med. 2024; 50(4):526-538.

PMID: 38546855 DOI: 10.1007/s00134-024-07381-z.

Strategies for Oxygen Ecosystems in Middle-Income Countries: A Review and Case Study from Lebanon.

Baker T, Gatti C, Rossini G, Tolla H, Detjen A, Mideksa M Emerg Med Int. 2024; 2024:9964636.

PMID: 38344746 PMC: 10857875. DOI: 10.1155/2024/9964636.

Oxygenation target in acute respiratory distress syndrome.

Capellier G, Barrot L, Winizewski H J Intensive Med. 2023; .

PMID: 37362867 PMC: 10181914. DOI: 10.1016/j.jointm.2023.03.002.

References

Hofmann R, James S, Jernberg T, Lindahl B, Erlinge D, Witt N . Oxygen Therapy in Suspected Acute Myocardial Infarction. N Engl J Med. 2017; 377(13):1240-1249. DOI: 10.1056/NEJMoa1706222. View

Foran M, Ahn R, Novik J, Tyer-Viola L, Chilufya K, Katamba K . Prevalence of undiagnosed hypoxemia in adults and children in an under-resourced district hospital in Zambia. Int J Emerg Med. 2011; 3(4):351-6. PMC: 3047821. DOI: 10.1007/s12245-010-0241-5. View

Helviz Y, Einav S . A Systematic Review of the High-flow Nasal Cannula for Adult Patients. Crit Care. 2018; 22(1):71. PMC: 5861611. DOI: 10.1186/s13054-018-1990-4. View

Nash G, BLENNERHASSETT J, PONTOPPIDAN H . Pulmonary lesions associated with oxygen therapy and artificial ventilation. N Engl J Med. 1967; 276(7):368-74. DOI: 10.1056/NEJM196702162760702. View

Roffe C, Nevatte T, Sim J, Bishop J, Ives N, Ferdinand P . Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial. JAMA. 2017; 318(12):1125-1135. PMC: 5818819. DOI: 10.1001/jama.2017.11463. View

Usher A . Medical oxygen crisis: a belated COVID-19 response. Lancet. 2021; 397(10277):868-869. PMC: 9752211. DOI: 10.1016/S0140-6736(21)00561-4. View

Belle J, Cohen H, Shindo N, Lim M, Velazquez-Berumen A, Ndihokubwayo J . Influenza preparedness in low-resource settings: a look at oxygen delivery in 12 African countries. J Infect Dev Ctries. 2010; 4(7):419-24. DOI: 10.3855/jidc.859. View

Echevarria C, Steer J, Wason J, Bourke S . Oxygen therapy and inpatient mortality in COPD exacerbation. Emerg Med J. 2020; 38(3):170-177. DOI: 10.1136/emermed-2019-209257. View

Pierson D . History and epidemiology of noninvasive ventilation in the acute-care setting. Respir Care. 2008; 54(1):40-52. View

10.

Schjorring O, Klitgaard T, Perner A, Wetterslev J, Lange T, Siegemund M . Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure. N Engl J Med. 2021; 384(14):1301-1311. DOI: 10.1056/NEJMoa2032510. View

11.

Tuti T, Aluvaala J, Akech S, Agweyu A, Irimu G, English M . Pulse oximetry adoption and oxygen orders at paediatric admission over 7 years in Kenya: a multihospital retrospective cohort study. BMJ Open. 2021; 11(9):e050995. PMC: 8424839. DOI: 10.1136/bmjopen-2021-050995. View

12.

Skrip L, Derra K, Kabore M, Noori N, Gansane A, Valea I . Clinical management and mortality among COVID-19 cases in sub-Saharan Africa: A retrospective study from Burkina Faso and simulated case analysis. Int J Infect Dis. 2020; 101:194-200. PMC: 7518969. DOI: 10.1016/j.ijid.2020.09.1432. View

13.

Brower R, Matthay M, Morris A, Schoenfeld D, Thompson B, Wheeler A . Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome. N Engl J Med. 2000; 342(18):1301-8. DOI: 10.1056/NEJM200005043421801. View

14.

Brugniaux J, Coombs G, Barak O, Dujic Z, Sekhon M, Ainslie P . Highs and lows of hyperoxia: physiological, performance, and clinical aspects. Am J Physiol Regul Integr Comp Physiol. 2018; 315(1):R1-R27. DOI: 10.1152/ajpregu.00165.2017. View

15.

Meduri G, Conoscenti C, Menashe P, Nair S . Noninvasive face mask ventilation in patients with acute respiratory failure. Chest. 1989; 95(4):865-70. DOI: 10.1378/chest.95.4.865. View

16.

Davies K . Oxidative stress: the paradox of aerobic life. Biochem Soc Symp. 1995; 61:1-31. DOI: 10.1042/bss0610001. View

17.

Duke T, Graham S, Cherian M, Ginsburg A, English M, Howie S . Oxygen is an essential medicine: a call for international action. Int J Tuberc Lung Dis. 2010; 14(11):1362-8. PMC: 2975100. View

18.

Maitland K, Kiguli S, Olupot-Olupot P, Hamaluba M, Thomas K, Alaroker F . Randomised controlled trial of oxygen therapy and high-flow nasal therapy in African children with pneumonia. Intensive Care Med. 2021; 47(5):566-576. PMC: 8098782. DOI: 10.1007/s00134-021-06385-3. View

19.

Helmerhorst H, Schultz M, van der Voort P, Bosman R, Juffermans N, de Jonge E . Self-reported attitudes versus actual practice of oxygen therapy by ICU physicians and nurses. Ann Intensive Care. 2014; 4:23. PMC: 4240734. DOI: 10.1186/s13613-014-0023-y. View

20.

Bellani G, Laffey J, Pham T, Fan E, Brochard L, Esteban A . Epidemiology, Patterns of Care, and Mortality for Patients With Acute Respiratory Distress Syndrome in Intensive Care Units in 50 Countries. JAMA. 2016; 315(8):788-800. DOI: 10.1001/jama.2016.0291. View