Higher Fasting Blood Glucose Was Associated with Worse In-hospital Clinical Outcomes in Patients with Primary Intracerebral Hemorrhage: From a Large-scale Nationwide Longitudinal Registry

Overview

Journal CNS Neurosci Ther

Specialties Neurology
Pharmacology

Date 2022 Sep 24

PMID 36152306

Authors

Guangshuo Li

Shang Wang

Yunyun Xiong

Hongqiu Gu

Yingyu Jiang

Xin Yang

Chunjuan Wang

Chuanying Wang

Zixiao Li

Xingquan Zhao

Affiliations

Soon will be listed here.

Abstract

Introduction: Studies that investigated the relationship between fasting blood glucose (FBG) and intracerebral hemorrhage (ICH) outcomes were insufficient.

Aim: We aimed to investigate the association between FBG level and in-hospital clinical outcomes in patients with primary ICH.

Results: A total of 34,507 patients were enrolled in the final study. Compared with the reference group, the ≥6.1 and <7 mmol/L group showed nonsignificant higher in-hospital mortality (adjusted odds ratio [OR] 1.20, 95% confidence interval [CI] 0.69-2.11, p = 0.52), and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 1.56, 95% CI 1.26-1.92, p < 0.001). The ≥7 mmol/L group showed both significant higher in-hospital mortality (adjusted OR 2.08, 95% CI 1.42-3.04, p = 0.52) and a significant higher proportion of intracranial hematoma evacuation (adjusted OR 2.09, 95% CI 1.78-2.47, p < 0.001).

Conclusion: Higher FBG level was correlated with both higher mortality and proportion of evacuation of intracranial hematoma.

Citing Articles

Stress-Induced Hyperglycemia Predicts Poor Outcomes in Primary Intracerebral Hemorrhage Patients.

Gilotra K, Basem J, Janssen M, Swarna S, Mani R, Ren B NeuroSci. 2025; 6(1).

PMID: 39982264 PMC: 11843840. DOI: 10.3390/neurosci6010012.

Higher fasting blood glucose was associated with worse in-hospital clinical outcomes in patients with primary intracerebral hemorrhage: From a large-scale nationwide longitudinal registry.

Li G, Wang S, Xiong Y, Gu H, Jiang Y, Yang X CNS Neurosci Ther. 2022; 28(12):2260-2267.

PMID: 36152306 PMC: 9627374. DOI: 10.1111/cns.13972.

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