DNA Repair Pathways As a Novel Therapeutic Strategy in Esophageal Cancer: A Review Study

Overview

Journal Cancer Rep (Hoboken)

Specialty Oncology

Date 2022 Sep 23

PMID 36147024

Authors

Mohammad Reza Kheyrandish

Seyed Mostafa Mir

Mehdi Sheikh Arabi

Affiliations

Soon will be listed here.

Abstract

Esophageal cancer (EC) is a common malignancy with a poor prognosis worldwide. There are two core pathways that repair double-strand breaks, homologous recombination (HR) and non-homologous end joining (NHEJ) and numerous proteins are recognized that affect the occurrence of HR and NHEJ. Altered DNA damage response (DDR) pathways are associated with cancer susceptibility and affect therapeutic response and resistance in cancers. DDR pathway alterations in EC are still poorly understood. Therefore, the identification of alterations in specific genes in DDR pathways may potentially result in novel treatments for resistant cancers, especially EC. In this review, we aimed to focus on different aspects of DNA damage and repair processes in EC. Also, we reviewed new therapeutic strategies via targeting DNA repair machinery components.

Citing Articles

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The Role of Long Noncoding RNAs (lncRNAs) in Esophageal Cancer Therapy Resistance and Metastasis.

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DNA repair pathways as a novel therapeutic strategy in esophageal cancer: A review study.

Kheyrandish M, Mostafa Mir S, Sheikh Arabi M Cancer Rep (Hoboken). 2022; 5(11):e1716.

PMID: 36147024 PMC: 9675361. DOI: 10.1002/cnr2.1716.

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