» Articles » PMID: 36146871

Human Virome in Cervix Controlled by the Domination of Human Papillomavirus

Overview
Journal Viruses
Publisher MDPI
Specialty Microbiology
Date 2022 Sep 23
PMID 36146871
Authors
Affiliations
Soon will be listed here.
Abstract

Although other co-viral infections could also be considered influencing factors, cervical human papillomavirus (HPV) infection is the main cause of cervical cancer. Metagenomics have been employed in the NGS era to study the microbial community in each habitat. Thus, in this investigation, virome capture sequencing was used to examine the virome composition in the HPV-infected cervix. Based on the amount of HPV present in each sample, the results revealed that the cervical virome of HPV-infected individuals could be split into two categories: HPV-dominated (HD; ≥60%) and non-HPV-dominated (NHD; <60%). Cervical samples contained traces of several human viral species, including the molluscum contagiosum virus (MCV), human herpesvirus 4 (HHV4), torque teno virus (TTV), and influenza A virus. When compared to the HD group, the NHD group had a higher abundance of several viruses. Human viral diversity appears to be influenced by HPV dominance. This is the first proof that the diversity of human viruses in the cervix is impacted by HPV abundance. However, more research is required to determine whether human viral variety and the emergence of cancer are related.

Citing Articles

The Vaginal Virome in Women's Health and Disease.

Orton K, Monaco C Microorganisms. 2025; 13(2).

PMID: 40005796 PMC: 11858017. DOI: 10.3390/microorganisms13020431.


Viruses in the female lower reproductive tract: a systematic descriptive review of metagenomic investigations.

Honorato L, Paiao H, da Costa A, Tozetto-Mendoza T, Mendes-Correa M, Witkin S NPJ Biofilms Microbiomes. 2024; 10(1):137.

PMID: 39587088 PMC: 11589587. DOI: 10.1038/s41522-024-00613-6.


Analyzing Cervical Microbiome Composition in HIV-Infected Women with Different HPV Infection Profiles: A Pilot Study in Thailand.

Preechasuth K, Brazier L, Khamduang W, Hongjaisee S, Wangsaeng N, Ngo-Giang-Huong N Microorganisms. 2024; 12(7).

PMID: 39065066 PMC: 11278691. DOI: 10.3390/microorganisms12071298.


The mysterious anelloviruses: investigating its role in human diseases.

Sabbaghian M, Gheitasi H, Shekarchi A, Tavakoli A, Poortahmasebi V BMC Microbiol. 2024; 24(1):40.

PMID: 38281930 PMC: 10823751. DOI: 10.1186/s12866-024-03187-7.


Special Issue "New Frontiers in Small DNA Virus Research".

Strati K, Pyeon D Viruses. 2023; 15(1).

PMID: 36680299 PMC: 9865906. DOI: 10.3390/v15010259.

References
1.
Kyrgiou M, Mitra A, Moscicki A . Does the vaginal microbiota play a role in the development of cervical cancer?. Transl Res. 2016; 179:168-182. PMC: 5164950. DOI: 10.1016/j.trsl.2016.07.004. View

2.
van der Burg S, Piersma S, de Jong A, van der Hulst J, Kwappenberg K, van den Hende M . Association of cervical cancer with the presence of CD4+ regulatory T cells specific for human papillomavirus antigens. Proc Natl Acad Sci U S A. 2007; 104(29):12087-92. PMC: 1924590. DOI: 10.1073/pnas.0704672104. View

3.
Landers R, OLeary J, Crowley M, HEALY I, Annis P, Burke L . Epstein-Barr virus in normal, pre-malignant, and malignant lesions of the uterine cervix. J Clin Pathol. 1993; 46(10):931-5. PMC: 501621. DOI: 10.1136/jcp.46.10.931. View

4.
Vafadar S, Shahdoust M, Kalirad A, Zakeri P, Sadeghi M . Competitive exclusion during co-infection as a strategy to prevent the spread of a virus: A computational perspective. PLoS One. 2021; 16(2):e0247200. PMC: 7904198. DOI: 10.1371/journal.pone.0247200. View

5.
Zhao Y, Cao X, Zheng Y, Tang J, Cai W, Wang H . Relationship between cervical disease and infection with human papillomavirus types 16 and 18, and herpes simplex virus 1 and 2. J Med Virol. 2012; 84(12):1920-7. DOI: 10.1002/jmv.23353. View