NOD1, NOD2, and NLRC5 Receptors in Antiviral and Antimycobacterial Immunity

Overview

Journal Vaccines (Basel)

Date 2022 Sep 23

PMID 36146565

Authors

Magdalena Godkowicz

Magdalena Druszczynska

Affiliations

Soon will be listed here.

Abstract

The innate immune system recognizes pathogen-associated molecular motifs through pattern recognition receptors (PRRs) that induce inflammasome assembly in macrophages and trigger signal transduction pathways, thereby leading to the transcription of inflammatory cytokine genes. Nucleotide-binding oligomerization domain (NOD)-like receptors (NLRs) represent a family of cytosolic PRRs involved in the detection of intracellular pathogens such as mycobacteria or viruses. In this review, we discuss the role of NOD1, NOD2, and NLRC5 receptors in regulating antiviral and antimycobacterial immune responses by providing insight into molecular mechanisms as well as their potential health and disease implications.

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