New Insights into the Structure Domain and Function of NLR Family CARD Domain Containing 5

Overview

Journal Cell Commun Signal

Publisher Biomed Central

Date 2025 Jan 24

PMID 39849460

Authors

Haiqing Zhu

Chengwei Xiao

Jiahua Chen

Bao Guo

Wenyan Wang

Zhenhai Tang

Yunxia Cao

Lei Zhan

Jun-Hui Zhang

Affiliations

Soon will be listed here.

Abstract

NOD-like receptor family CARD domain-containing 5 (NLRC5) is a major transcriptional coactivator of MHC class I genes. NLRC5 is the largest member of the NLR family and contains three domains: an untypical caspase recruitment domain (uCARD), a central nucleotide-binding and oligomerization domain (NOD or NACHT), and a leucine-rich repeat (LRR) domain. The functional variability of NLRC5 has been attributed to its different domain interactions with specific ligands in different cell types. In this review, we address the molecular mechanisms and their implications in multiple microenvironments based on the different functional domains of NLRC5.

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