Extracellular Vesicles: A New Frontier for Cardiac Repair

Overview

Journal Pharmaceutics

Publisher MDPI

Date 2022 Sep 23

PMID 36145595

Authors

Benshuai You

Yang Yang

Zixuan Zhou

Yongmin Yan

Leilei Zhang

Jianhua Jin

Hui Qian

Affiliations

Soon will be listed here.

Abstract

The ability of extracellular vesicles (EVs) to regulate a broad range of cellular processes has recently been used to treat diseases. Growing evidence indicates that EVs play a cardioprotective role in heart disease by activating beneficial signaling pathways. Multiple functional components of EVs and intracellular molecular mechanisms are involved in the process. To overcome the shortcomings of native EVs such as their heterogeneity and limited tropism, a series of engineering approaches has been developed to improve the therapeutic efficiency of EVs. In this review, we present an overview of the research and future directions for EVs-based cardiac therapies with an emphasis on EVs-mediated delivery of therapeutic agents. The advantages and limitations of various modification strategies are discussed, and possible opportunities for improvement are proposed. An in-depth understanding of the endogenous properties of EVs and EVs engineering strategies could lead to a promising cell-free therapy for cardiac repair.

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