Biomimetic and Immunomodulatory Therapeutics As an Alternative to Natural Exosomes for Vascular and Cardiac Applications

Overview

Journal Nanomedicine

Publisher Elsevier

Specialties Biomedical Engineering
Biotechnology

Date 2021 Mar 28

PMID 33774130

Citations 7

Authors

Ramiro A Villarreal-Leal

John P Cooke

Bruna Corradetti

Affiliations

Soon will be listed here.

Abstract

Inflammation is a central mechanism in cardiovascular diseases (CVD), where sustained oxidative stress and immune responses contribute to cardiac remodeling and impairment. Exosomes are extracellular vesicles released by cells to communicate with their surroundings and to modulate the tissue microenvironment. Recent evidence indicates their potential as cell-free immunomodulatory therapeutics for CVD, preventing cell death and fibrosis while inducing wound healing and angiogenesis. Biomimetic exosomes are semi-synthetic particles engineered using essential moieties present in natural exosomes (lipids, RNA, proteins) to reproduce their therapeutic effects while improving on scalability and standardization due to the ample range of moieties available to produce them. In this review, we provide an up-to-date description of the use of exosomes for CVD and offer our vision on the areas of opportunity for the development of biomimetic strategies. We also discuss the current limitations to overcome in the process towards their translation into clinic.

Citing Articles

Extracellular vesicle therapeutics for cardiac repair.

Hu Y, Zhang W, Ali S, Takeda K, Vahl T, Zhu D J Mol Cell Cardiol. 2024; 199:12-32.

PMID: 39603560 PMC: 11788051. DOI: 10.1016/j.yjmcc.2024.11.005.

Targeted drug delivery of engineered mesenchymal stem/stromal-cell-derived exosomes in cardiovascular disease: recent trends and future perspectives.

Pang J, Shao H, Xu X, Lin Z, Chen X, Chen J Front Bioeng Biotechnol. 2024; 12:1363742.

PMID: 38558788 PMC: 10978787. DOI: 10.3389/fbioe.2024.1363742.

Programming assembly of biomimetic exosomes: An emerging theranostic nanomedicine platform.

Xu X, Xu L, Wen C, Xia J, Zhang Y, Liang Y Mater Today Bio. 2023; 22:100760.

PMID: 37636982 PMC: 10450992. DOI: 10.1016/j.mtbio.2023.100760.

Roles and therapeutic potential of different extracellular vesicle subtypes on traumatic brain injury.

Dong X, Dong J, Zhang J Cell Commun Signal. 2023; 21(1):211.

PMID: 37596642 PMC: 10436659. DOI: 10.1186/s12964-023-01165-6.

Extracellular Vesicles: A New Frontier for Cardiac Repair.

You B, Yang Y, Zhou Z, Yan Y, Zhang L, Jin J Pharmaceutics. 2022; 14(9).

PMID: 36145595 PMC: 9503573. DOI: 10.3390/pharmaceutics14091848.

References

Singla D, Johnson T, Tavakoli Dargani Z . Exosome Treatment Enhances Anti-Inflammatory M2 Macrophages and Reduces Inflammation-Induced Pyroptosis in Doxorubicin-Induced Cardiomyopathy. Cells. 2019; 8(10). PMC: 6830113. DOI: 10.3390/cells8101224. View

Xiao J, Pan Y, Li X, Yang X, Feng Y, Tan H . Cardiac progenitor cell-derived exosomes prevent cardiomyocytes apoptosis through exosomal miR-21 by targeting PDCD4. Cell Death Dis. 2016; 7(6):e2277. PMC: 5143405. DOI: 10.1038/cddis.2016.181. View

Rossello X, He Z, Yellon D . Myocardial Infarct Size Reduction Provided by Local and Remote Ischaemic Preconditioning: References Values from the Hatter Cardiovascular Institute. Cardiovasc Drugs Ther. 2018; 32(2):127-133. PMC: 5958157. DOI: 10.1007/s10557-018-6788-8. View

Zhang H, Liu J, Qu D, Wang L, Wong C, Lau C . Serum exosomes mediate delivery of arginase 1 as a novel mechanism for endothelial dysfunction in diabetes. Proc Natl Acad Sci U S A. 2018; 115(29):E6927-E6936. PMC: 6055191. DOI: 10.1073/pnas.1721521115. View

Cesselli D, Beltrami A, DAurizio F, Marcon P, Bergamin N, Toffoletto B . Effects of age and heart failure on human cardiac stem cell function. Am J Pathol. 2011; 179(1):349-66. PMC: 3175070. DOI: 10.1016/j.ajpath.2011.03.036. View

Antimisiaris S, Mourtas S, Marazioti A . Exosomes and Exosome-Inspired Vesicles for Targeted Drug Delivery. Pharmaceutics. 2018; 10(4). PMC: 6321407. DOI: 10.3390/pharmaceutics10040218. View

Meng S, Zhou G, Gu Q, Chanda P, Ospino F, Cooke J . Transdifferentiation Requires iNOS Activation: Role of RING1A S-Nitrosylation. Circ Res. 2016; 119(9):e129-e138. PMC: 5065398. DOI: 10.1161/CIRCRESAHA.116.308263. View

Cooke J . Inflammation and Its Role in Regeneration and Repair. Circ Res. 2019; 124(8):1166-1168. PMC: 6578588. DOI: 10.1161/CIRCRESAHA.118.314669. View

Palomba R, Parodi A, Evangelopoulos M, Acciardo S, Corbo C, De Rosa E . Biomimetic carriers mimicking leukocyte plasma membrane to increase tumor vasculature permeability. Sci Rep. 2016; 6:34422. PMC: 5050497. DOI: 10.1038/srep34422. View

10.

Hu Q, Su H, Li J, Lyon C, Tang W, Wan M . Clinical applications of exosome membrane proteins. Precis Clin Med. 2020; 3(1):54-66. PMC: 7099650. DOI: 10.1093/pcmedi/pbaa007. View

11.

Gallina C, Turinetto V, Giachino C . A New Paradigm in Cardiac Regeneration: The Mesenchymal Stem Cell Secretome. Stem Cells Int. 2015; 2015:765846. PMC: 4436518. DOI: 10.1155/2015/765846. View

12.

Shin H, Han C, Labuz J, Kim J, Kim J, Cho S . High-yield isolation of extracellular vesicles using aqueous two-phase system. Sci Rep. 2015; 5:13103. PMC: 4536486. DOI: 10.1038/srep13103. View

13.

Loyer X, Zlatanova I, Devue C, Yin M, Howangyin K, Klaihmon P . Intra-Cardiac Release of Extracellular Vesicles Shapes Inflammation Following Myocardial Infarction. Circ Res. 2018; 123(1):100-106. PMC: 6023578. DOI: 10.1161/CIRCRESAHA.117.311326. View

14.

Mentkowski K, Mursleen A, Snitzer J, Euscher L, Lang J . CDC-derived extracellular vesicles reprogram inflammatory macrophages to an arginase 1-dependent proangiogenic phenotype. Am J Physiol Heart Circ Physiol. 2020; 318(6):H1447-H1460. PMC: 7311701. DOI: 10.1152/ajpheart.00155.2020. View

15.

Guo Y, Bao S, Guo W, Diao Z, Wang L, Han X . Bone marrow mesenchymal stem cell-derived exosomes alleviate high phosphorus-induced vascular smooth muscle cells calcification by modifying microRNA profiles. Funct Integr Genomics. 2019; 19(4):633-643. DOI: 10.1007/s10142-019-00669-0. View

16.

Li P, Liu Z, Xie Y, Gu H, Dai Q, Yao J . Serum Exosomes Attenuate HO-Induced Apoptosis in Rat H9C2 Cardiomyocytes via ERK1/2. J Cardiovasc Transl Res. 2018; 12(1):37-44. DOI: 10.1007/s12265-018-9791-3. View

17.

Tong Y, Ye C, Ren X, Qiu Y, Zang Y, Xiong X . Exosome-Mediated Transfer of ACE (Angiotensin-Converting Enzyme) From Adventitial Fibroblasts of Spontaneously Hypertensive Rats Promotes Vascular Smooth Muscle Cell Migration. Hypertension. 2018; 72(4):881-888. DOI: 10.1161/HYPERTENSIONAHA.118.11375. View

18.

Garg P, Ghatmale P, Tarwadi K, Chavan S . Influence of Nanotechnology and the Role of Nanostructures in Biomimetic Studies and Their Potential Applications. Biomimetics (Basel). 2019; 2(2). PMC: 6477628. DOI: 10.3390/biomimetics2020007. View

19.

Wider J, Undyala V, Whittaker P, Woods J, Chen X, Przyklenk K . Remote ischemic preconditioning fails to reduce infarct size in the Zucker fatty rat model of type-2 diabetes: role of defective humoral communication. Basic Res Cardiol. 2018; 113(3):16. PMC: 6776086. DOI: 10.1007/s00395-018-0674-1. View

20.

Lin W, Wang H, Chen Y, Lin C, Fan H, Lee Y . Gene Modified CAR-T Cellular Therapy for Hematologic Malignancies. Int J Mol Sci. 2020; 21(22). PMC: 7697548. DOI: 10.3390/ijms21228655. View