The Role of Cadherin 12 (CDH12) in the Peritoneal Fluid Among Patients with Endometriosis and Endometriosis-Related Infertility

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Sep 23

PMID 36141853

Authors

Ksawery Golawski

Robert Soczewica

Joanna Kacperczyk-Bartnik

Grzegorz Manka

Mariusz Kiecka

Michal Lipa

Damian Warzecha

Robert Spaczynski

Piotr Piekarski

Beata Banaszewska

Artur Jakimiuk

Tadeusz Issat

Wojciech Rokita

Jakub Mlodawski

Maria Szubert

Piotr Sieroszewski

Grzegorz Raba

Kamil Szczupak

Tomasz Kluz

Marek Kluza

Miroslaw Wielgos

Ewa Koc-Zorawska

Marcin Zorawski

Piotr Laudanski

Affiliations

Soon will be listed here.

Abstract

Cadherin 12 (CDH 12) can play a role in the pathogenesis of endometriosis. The aim of this study was to compare the levels of cadherin 12 in the peritoneal fluid between women with and without endometriosis. This was a multicenter cross-sectional study. Eighty-two patients undergoing laparoscopic procedures were enrolled in the study. Cadherin 12 concentrations were determined using the enzyme-linked immunosorbent assay. The level of statistical significance was set at < 0.05. No differences in cadherin 12 concentrations between patients with and without endometriosis were observed ( = 0.4). Subgroup analyses showed that CDH 12 concentrations were significantly higher in patients with infertility or primary infertility and endometriosis in comparison with patients without endometriosis and without infertility or primary infertility ( = 0.02) and also higher in patients with stage I or II endometriosis and infertility or primary infertility than in patients without endometriosis and infertility or primary infertility ( = 0.03, = 0.048, respectively). In total, CDH 12 levels were significantly higher in patients diagnosed with infertility or primary infertility ( = 0.0092, = 0.009, respectively) than in fertile women. Cadherin 12 can possibly play a role in the pathogenesis of infertility, both in women with and without endometriosis.

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