Plasma and Peritoneal Poly (ADP-Ribose) Polymerase Levels in Patients with Endometriosis

Overview

Journal Biomedicines

Specialty Biomedical Engineering

Date 2022 Oct 27

PMID 36289716

Authors

Joanna Kacperczyk-Bartnik

Pawel Bartnik

Ksawery Golawski

Janusz Sierdzinski

Grzegorz Manka

Mariusz Kiecka

Michal Lipa

Damian Warzecha

Robert Spaczynski

Piotr Piekarski

Beata Banaszewska

Artur Jakimiuk

Tadeusz Issat

Wojciech Rokita

Jakub Mlodawski

Maria Szubert

Piotr Sieroszewski

Grzegorz Raba

Kamil Szczupak

Tomasz Kluz

Marek Kluza

Krzysztof Czajkowski

Miroslaw Wielgos

Ewa Koc-Zorawska

Marcin Zorawski

Piotr Laudanski

Affiliations

Soon will be listed here.

Abstract

The evidence of poly (ADP-ribose) polymerase (PARP) association with the immune response could be coherent with the immunological theory of endometriosis and suggests the possibility of a new research direction. The aim of the study was to evaluate the levels of PARP in plasma and peritoneal fluid of patients with and without endometriosis. It was a multicenter, cross-sectional study. Plasma and peritoneal fluid samples were collected from patients with and without endometriosis during planned laparoscopic procedures in eight clinical centers. In total, 84 samples of plasma and 84 samples of the peritoneal fluid were included in the final analyses. Double-antibody sandwich enzyme-linked immunosorbent assay was performed in order to assess levels of PARP in collected samples. No statistically significant differences regarding the detected levels of PARP in plasma and peritoneal fluid comparing patients with and without endometriosis were observed. Patients with a history of infertility had significantly higher plasma PARP concentrations ( = 0.04). We have not observed the potential role of PARP concentration levels in plasma nor peritoneal fluid as an endometriosis biomarker. We have determined an association between a higher plasma PARP concentration and a history of infertility.

Citing Articles

Is the leptin/BMI ratio a reliable biomarker for endometriosis?.

Zygula A, Sankiewicz A, Sakowicz A, Dobrzynska E, Dakowicz A, Manka G Front Endocrinol (Lausanne). 2024; 15:1359182.

PMID: 38567305 PMC: 10985179. DOI: 10.3389/fendo.2024.1359182.

Investigation of the Changes in Concentrations of Vitamin D-Binding Protein and Lactoferin in Plasma and Peritoneal Fluid of Patients with Endometriosis.

Lisowska-Myjak B, Skarzynska E, Wrobel M, Manka G, Kiecka M, Lipa M Int J Mol Sci. 2023; 24(9).

PMID: 37175534 PMC: 10178223. DOI: 10.3390/ijms24097828.

An Array SPRi Biosensor for the Determination on PARP-1 in Blood Plasma.

Zielinska Z, Oldak L, Kacperczyk-Bartnik J, Koc-Zorawska E, Zorawski M, Laudanski P Biomedicines. 2023; 11(2).

PMID: 36831138 PMC: 9953221. DOI: 10.3390/biomedicines11020602.

Plasma and Peritoneal Fluid Fibronectin and Collagen IV Levels as Potential Biomarkers of Endometriosis.

Warzecha D, Zalecka J, Manka G, Kiecka M, Lipa M, Spaczynski R Int J Mol Sci. 2022; 23(24).

PMID: 36555313 PMC: 9778765. DOI: 10.3390/ijms232415669.

References

Barreta A, Sarian L, Ferracini A, Bastos Eloy Costa L, Mazzola P, de Angelo Andrade L . Immunohistochemistry expression of targeted therapies biomarkers in ovarian clear cell and endometrioid carcinomas (type I) and endometriosis. Hum Pathol. 2018; 85:72-81. DOI: 10.1016/j.humpath.2018.10.028. View

Koninckx P, Kennedy S, Barlow D . Endometriotic disease: the role of peritoneal fluid. Hum Reprod Update. 1999; 4(5):741-51. DOI: 10.1093/humupd/4.5.741. View

Talebi H, Farahpour M, Hamishehkar H . The effectiveness of Rutin for prevention of surgical induced endometriosis development in a rat model. Sci Rep. 2021; 11(1):7180. PMC: 8010059. DOI: 10.1038/s41598-021-86586-4. View

. Revised American Society for Reproductive Medicine classification of endometriosis: 1996. Fertil Steril. 1997; 67(5):817-21. DOI: 10.1016/s0015-0282(97)81391-x. View

Laudanski P, Szamatowicz J, Oniszczuk M . Profiling of peritoneal fluid of women with endometriosis by chemokine protein array. Adv Med Sci. 2007; 51:148-52. View

Hornstein M, Thomas P, Sober A, Wyshak G, Albright N, Frisch R . Association between endometriosis, dysplastic naevi and history of melanoma in women of reproductive age. Hum Reprod. 1997; 12(1):143-5. DOI: 10.1093/humrep/12.1.143. View

Sourial S, Tempest N, Hapangama D . Theories on the pathogenesis of endometriosis. Int J Reprod Med. 2015; 2014:179515. PMC: 4334056. DOI: 10.1155/2014/179515. View

Laudanski P, Charkiewicz R, Kuzmicki M, Szamatowicz J, Swiatecka J, Mroczko B . Profiling of selected angiogenesis-related genes in proliferative eutopic endometrium of women with endometriosis. Eur J Obstet Gynecol Reprod Biol. 2013; 172:85-92. DOI: 10.1016/j.ejogrb.2013.10.007. View

HOUSTON D . Evidence for the risk of pelvic endometriosis by age, race and socioeconomic status. Epidemiol Rev. 1984; 6:167-91. DOI: 10.1093/oxfordjournals.epirev.a036270. View

10.

Joshi A, Mahfooz S, Maurya V, Kumar V, Basanna C, Kaur G . PARP1 during embryo implantation and its upregulation by oestradiol in mice. Reproduction. 2014; 147(6):765-80. DOI: 10.1530/REP-13-0588. View

11.

Brinton L, Gridley G, Persson I, Baron J, Bergqvist A . Cancer risk after a hospital discharge diagnosis of endometriosis. Am J Obstet Gynecol. 1997; 176(3):572-9. DOI: 10.1016/s0002-9378(97)70550-7. View

12.

DAmours D, Desnoyers S, DSilva I, Poirier G . Poly(ADP-ribosyl)ation reactions in the regulation of nuclear functions. Biochem J. 1999; 342 ( Pt 2):249-68. PMC: 1220459. View

13.

Van Weemen B, Schuurs A . Immunoassay using antigen-enzyme conjugates. FEBS Lett. 1971; 15(3):232-236. DOI: 10.1016/0014-5793(71)80319-8. View

14.

Szamatowicz J, Laudanski P, Tomaszewska I, Szamatowicz M . Chemokine growth-regulated-alpha: a possible role in the pathogenesis of endometriosis. Gynecol Endocrinol. 2002; 16(2):137-41. View

15.

Swiersz L . Role of endometriosis in cancer and tumor development. Ann N Y Acad Sci. 2002; 955:281-92; discussion 293-5, 396-406. DOI: 10.1111/j.1749-6632.2002.tb02788.x. View

16.

Wani W, Sunkaria A, Sharma D, Kandimalla R, Kaushal A, Gerace E . Caspase inhibition augments Dichlorvos-induced dopaminergic neuronal cell death by increasing ROS production and PARP1 activation. Neuroscience. 2013; 258:1-15. DOI: 10.1016/j.neuroscience.2013.11.004. View

17.

Rahmioglu N, Fassbender A, Vitonis A, Tworoger S, Hummelshoj L, DHooghe T . World Endometriosis Research Foundation Endometriosis Phenome and Biobanking Harmonization Project: III. Fluid biospecimen collection, processing, and storage in endometriosis research. Fertil Steril. 2014; 102(5):1233-43. PMC: 4230639. DOI: 10.1016/j.fertnstert.2014.07.1208. View

18.

Wang C, Du M, Huang D, Huang K, Huang K . Inhibition of PARP1 Increases IRF-dependent Gene Transcription in Jurkat Cells. Curr Med Sci. 2019; 39(3):356-362. DOI: 10.1007/s11596-019-2043-1. View

19.

Sensky T, Liu D . Endometriosis: associations with menorrhagia, infertility and oral contraceptives. Int J Gynaecol Obstet. 1980; 17(6):573-6. DOI: 10.1002/j.1879-3479.1980.tb00210.x. View

20.

Soni U, Chadchan S, Joshi A, Kumar V, Maurya V, Verma R . Poly(ADP-ribose) polymerase-2 is essential for endometrial receptivity and blastocyst implantation, and regulated by caspase-8. Mol Cell Endocrinol. 2020; 518:110946. DOI: 10.1016/j.mce.2020.110946. View