The Utility of L. in Internal Medicine and In Dentistry: A Comprehensive Review

Overview

Journal Int J Environ Res Public Health

Publisher MDPI

Specialties Environmental Health
Public Health

Date 2022 Sep 23

PMID 36141454

Authors

Luciano Maria Catalfamo

Giulia Marrone

Michele Basilicata

Ilaria Vivarini

Vincenza Paolino

David Della-Morte

Francesco Saverio De Ponte

Francesca Di Daniele

Domenico Quattrone

Danilo De Rinaldis

Patrizio Bollero

Nicola Di Daniele

Annalisa Noce

Affiliations

Soon will be listed here.

Abstract

Capsaicin is a chili peppers extract, genus Capsicum, commonly used as a food spice. Since ancient times, Capsaicin has been used as a "homeopathic remedy" for treating a wild range of pathological conditions but without any scientific knowledge about its action. Several studies have demonstrated its potentiality in cardiovascular, nephrological, nutritional, and other medical fields. Capsaicin exerts its actions thanks to the bond with transient receptor potential vanilloid subtype 1 (TRPV1). TRPV1 is a nociceptive receptor, and its activation starts with a neurosensitive impulse, responsible for a burning pain sensation. However, constant local application of Capsaicin desensitized neuronal cells and leads to relief from neuropathic pain. In this review, we analyze the potential adjuvant role of Capsaicin in the treatment of different pathological conditions either in internal medicine or dentistry. Moreover, we present our experience in five patients affected by oro-facial pain consequent to post-traumatic trigeminal neuropathy, not responsive to any remedy, and successfully treated with topical application of Capsaicin. The topical application of Capsaicin is safe, effective, and quite tolerated by patients. For these reasons, in addition to the already-proven beneficial actions in the internal field, it represents a promising method for the treatment of neuropathic oral diseases.

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References

Alawi K, Keeble J . The paradoxical role of the transient receptor potential vanilloid 1 receptor in inflammation. Pharmacol Ther. 2009; 125(2):181-95. DOI: 10.1016/j.pharmthera.2009.10.005. View

Kichko T, Neuhuber W, Kobal G, Reeh P . The roles of TRPV1, TRPA1 and TRPM8 channels in chemical and thermal sensitivity of the mouse oral mucosa. Eur J Neurosci. 2017; 47(3):201-210. DOI: 10.1111/ejn.13799. View

Lee G, Shin M, Yoon D, Kim A, Yu R, Park N . Topical application of capsaicin reduces visceral adipose fat by affecting adipokine levels in high-fat diet-induced obese mice. Obesity (Silver Spring). 2013; 21(1):115-22. DOI: 10.1002/oby.20246. View

Fattori V, Hohmann M, Rossaneis A, Pinho-Ribeiro F, Verri W . Capsaicin: Current Understanding of Its Mechanisms and Therapy of Pain and Other Pre-Clinical and Clinical Uses. Molecules. 2016; 21(7). PMC: 6273101. DOI: 10.3390/molecules21070844. View

Rosenbaum T, Gordon-Shaag A, Munari M, Gordon S . Ca2+/calmodulin modulates TRPV1 activation by capsaicin. J Gen Physiol. 2003; 123(1):53-62. PMC: 2217413. DOI: 10.1085/jgp.200308906. View

Kim Y, Park Y, Yang S, Kim S, Hyun S, Cho S . Hypoxanthine levels in human urine serve as a screening indicator for the plasma total cholesterol and low-density lipoprotein modulation activities of fermented red pepper paste. Nutr Res. 2010; 30(7):455-61. DOI: 10.1016/j.nutres.2010.06.014. View

Moayedi Y, Duenas-Bianchi L, Lumpkin E . Somatosensory innervation of the oral mucosa of adult and aging mice. Sci Rep. 2018; 8(1):9975. PMC: 6028454. DOI: 10.1038/s41598-018-28195-2. View

Yilmaz Z, Egbuniwe O, Renton T . The Detection of Small-Fiber Neuropathies in Burning Mouth Syndrome and Iatrogenic Lingual Nerve Injuries: Use of Quantitative Sensory Testing. J Oral Facial Pain Headache. 2016; 30(2):87-98. DOI: 10.11607/ofph.1531. View

Modly C, Das M, Don P, Marcelo C, Mukhtar H, Bickers D . Capsaicin as an in vitro inhibitor of benzo(a)pyrene metabolism and its DNA binding in human and murine keratinocytes. Drug Metab Dispos. 1986; 14(4):413-6. View

10.

Gregor D, Zuo W, Fu R, Bekker A, Ye J . Elevation of Transient Receptor Potential Vanilloid 1 Function in the Lateral Habenula Mediates Aversive Behaviors in Alcohol-withdrawn Rats. Anesthesiology. 2019; 130(4):592-608. PMC: 6417946. DOI: 10.1097/ALN.0000000000002615. View

11.

Otunola G, Oloyede O, Oladiji A, Afolayan A . Selected spices and their combination modulate hypercholesterolemia-induced oxidative stress in experimental rats. Biol Res. 2014; 47:5. PMC: 4060372. DOI: 10.1186/0717-6287-47-5. View

12.

Raber-Durlacher J, Elad S, Barasch A . Oral mucositis. Oral Oncol. 2010; 46(6):452-6. DOI: 10.1016/j.oraloncology.2010.03.012. View

13.

Filipczak-Bryniarska I, Krzyzewski R, Kucharz J, Michalowska-Kaczmarczyk A, Kleja J, Woron J . High-dose 8% capsaicin patch in treatment of chemotherapy-induced peripheral neuropathy: single-center experience. Med Oncol. 2017; 34(9):162. PMC: 5561154. DOI: 10.1007/s12032-017-1015-1. View

14.

Kim S, Hwang J, Park H, Kwon D, Kim M . Capsaicin stimulates glucose uptake in C2C12 muscle cells via the reactive oxygen species (ROS)/AMPK/p38 MAPK pathway. Biochem Biophys Res Commun. 2013; 439(1):66-70. DOI: 10.1016/j.bbrc.2013.08.027. View

15.

Choi S, Shin Y, Namkoong E, Hwang S, Cong X, Yu G . TRPV1 in Salivary Gland Epithelial Cells Is Not Involved in Salivary Secretion via Transcellular Pathway. Korean J Physiol Pharmacol. 2015; 18(6):525-30. PMC: 4296043. DOI: 10.4196/kjpp.2014.18.6.525. View

16.

Rios-Silva M, Santos-Alvarez R, Trujillo X, Cardenas-Maria R, Lopez-Zamudio M, Bricio-Barrios J . Effects of Chronic Administration of Capsaicin on Biomarkers of Kidney Injury in Male Wistar Rats with Experimental Diabetes. Molecules. 2018; 24(1). PMC: 6337195. DOI: 10.3390/molecules24010036. View

17.

Kang J, Goto T, Han I, Kawada T, Kim Y, Yu R . Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet. Obesity (Silver Spring). 2009; 18(4):780-7. DOI: 10.1038/oby.2009.301. View

18.

Hammond J, Hammond R . Molecular cloning, sequencing and expression in Escherichia coli of the bean yellow mosaic virus coat protein gene. J Gen Virol. 1989; 70 ( Pt 8):1961-74. DOI: 10.1099/0022-1317-70-8-1961. View

19.

Surh Y, Lee S . Capsaicin in hot chili pepper: carcinogen, co-carcinogen or anticarcinogen?. Food Chem Toxicol. 1996; 34(3):313-6. DOI: 10.1016/0278-6915(95)00108-5. View

20.

Virus R, Knuepfer M, McManus D, BRODY M, Gebhart G . Capsaicin treatment in adult Wistar-Kyoto and spontaneously hypertensive rats: effects on nociceptive behavior and cardiovascular regulation. Eur J Pharmacol. 1981; 72(2-3):209-17. DOI: 10.1016/0014-2999(81)90275-2. View