Quantum Dot-Based Lateral Flow Immunoassay As Point-of-Care Testing for Infectious Diseases: A Narrative Review of Its Principle and Performance

Overview

Journal Diagnostics (Basel)

Specialty Radiology

Date 2022 Sep 23

PMID 36140559

Authors

Mohamad Ahmad Najib

Kasturi Selvam

Muhammad Fazli Khalid

Mehmet Ozsoz

Ismail Aziah

Affiliations

Soon will be listed here.

Abstract

Infectious diseases are the world's greatest killers, accounting for millions of deaths worldwide annually, especially in low-income countries. As the risk of emerging infectious diseases is increasing, it is critical to rapidly diagnose infections in the early stages and prevent further transmission. However, current detection strategies are time-consuming and have exhibited low sensitivity. Numerous studies revealed the advantages of point-of-care testing, such as those which are rapid, user-friendly and have high sensitivity and specificity, and can be performed at a patient's bedside. The Lateral Flow Immunoassay (LFIA) is the most popular diagnostic assay that fulfills the POCT standards. However, conventional AuNPs-LFIAs are moderately sensitive, meaning that rapid detection remains a challenge. Here, we review quantum dot (QDs)-based LFIA for highly sensitive rapid diagnosis of infectious diseases. We briefly describe the principles of LFIA, strategies for applying QDs to enhance sensitivity, and the published performance of the QD-LFIA tested against several infectious diseases.

Citing Articles

Allergen Microarrays and New Physical Approaches to More Sensitive and Specific Detection of Allergen-Specific Antibodies.

Sokolov P, Evsegneeva I, Karaulov A, Sukhanova A, Nabiev I Biosensors (Basel). 2024; 14(7).

PMID: 39056629 PMC: 11275078. DOI: 10.3390/bios14070353.

Exploring Simple Particle-Based Signal Amplification Strategies in a Heterogeneous Sandwich Immunoassay with Optical Detection.

Geissler D, Wegner K, Fischer C, Resch-Genger U Anal Chem. 2024; 96(13):5078-5085.

PMID: 38498677 PMC: 10993196. DOI: 10.1021/acs.analchem.3c03691.

Development of ZnCdSe/ZnS quantum dot-based fluorescence immunochromatographic assay for the rapid visual and quantitative detection 25⁃hydroxyvitamins D in human serum.

Wang J, Sun G, Li F, Zhu Z, Sun L, Lv P Front Bioeng Biotechnol. 2024; 11:1326254.

PMID: 38188486 PMC: 10766695. DOI: 10.3389/fbioe.2023.1326254.

Recent Advances in Quantum Dot-Based Lateral Flow Immunoassays for the Rapid, Point-of-Care Diagnosis of COVID-19.

Mousavi S, Kalashgrani M, Gholami A, Omidifar N, Binazadeh M, Chiang W Biosensors (Basel). 2023; 13(8).

PMID: 37622872 PMC: 10452855. DOI: 10.3390/bios13080786.

Advancements of Nanotechnology and Nanomaterials in Environmental and Human Protection for Combatting the COVID-19 During and Post-pandemic Era: A Comprehensive Scientific Review.

Wibowo Y, Ramadan B, Taher T, Khairurrijal K Biomed Mater Devices. 2023; :1-24.

PMID: 37363141 PMC: 10171735. DOI: 10.1007/s44174-023-00086-9.

References

Yan X, Wang K, Lu W, Qin W, Cui D, He J . CdSe/ZnS Quantum Dot-Labeled Lateral Flow Strips for Rapid and Quantitative Detection of Gastric Cancer Carbohydrate Antigen 72-4. Nanoscale Res Lett. 2016; 11(1):138. PMC: 4788655. DOI: 10.1186/s11671-016-1355-3. View

Schroeder K, Goreham R, Nann T . Graphene Quantum Dots for Theranostics and Bioimaging. Pharm Res. 2016; 33(10):2337-57. DOI: 10.1007/s11095-016-1937-x. View

Kim J, Cao X, Finkelstein J, Cardenas W, Erickson D, Mehta S . A two-colour multiplexed lateral flow immunoassay system to differentially detect human malaria species on a single test line. Malar J. 2019; 18(1):313. PMC: 6749696. DOI: 10.1186/s12936-019-2957-x. View

Koczula K, Gallotta A . Lateral flow assays. Essays Biochem. 2016; 60(1):111-20. PMC: 4986465. DOI: 10.1042/EBC20150012. View

Hwang E, Hwang H, Shin Y, Yoon Y, Lee H, Yang J . Chemically modulated graphene quantum dot for tuning the photoluminescence as novel sensory probe. Sci Rep. 2016; 6:39448. PMC: 5171703. DOI: 10.1038/srep39448. View

Kim C, Yoo Y, Han S, Lee J, Lee D, Lee K . Battery operated preconcentration-assisted lateral flow assay. Lab Chip. 2017; 17(14):2451-2458. DOI: 10.1039/c7lc00036g. View

Berlina A, Taranova N, Zherdev A, Vengerov Y, Dzantiev B . Quantum dot-based lateral flow immunoassay for detection of chloramphenicol in milk. Anal Bioanal Chem. 2013; 405(14):4997-5000. DOI: 10.1007/s00216-013-6876-3. View

Yang H, Li D, He R, Guo Q, Wang K, Zhang X . A novel quantum dots-based point of care test for syphilis. Nanoscale Res Lett. 2010; 5(5):875-81. PMC: 2893857. DOI: 10.1007/s11671-010-9578-1. View

Zhou R, Yin W, Li W, Wang Y, Lu J, Li Z . Prediction Model for Infectious Disease Health Literacy Based on Synthetic Minority Oversampling Technique Algorithm. Comput Math Methods Med. 2022; 2022:8498159. PMC: 8975663. DOI: 10.1155/2022/8498159. View

10.

Liu Y, Zhan L, Qin Z, Sackrison J, Bischof J . Ultrasensitive and Highly Specific Lateral Flow Assays for Point-of-Care Diagnosis. ACS Nano. 2021; 15(3):3593-3611. DOI: 10.1021/acsnano.0c10035. View

11.

Takalkar S, Baryeh K, Liu G . Fluorescent carbon nanoparticle-based lateral flow biosensor for ultrasensitive detection of DNA. Biosens Bioelectron. 2017; 98:147-154. PMC: 5556692. DOI: 10.1016/j.bios.2017.06.045. View

12.

Zhang X, Wu C, Wen K, Jiang H, Shen J, Zhang S . Comparison of Fluorescent Microspheres and Colloidal Gold as Labels in Lateral Flow Immunochromatographic Assays for the Detection of T-2 Toxin. Molecules. 2016; 21(1):E27. PMC: 6273043. DOI: 10.3390/molecules21010027. View

13.

Weigl B, Neogi T, McGuire H . Point-of-Care Diagnostics in Low-Resource Settings and Their Impact on Care in the Age of the Noncommunicable and Chronic Disease Epidemic. J Lab Autom. 2013; 19(3):248-57. DOI: 10.1177/2211068213515246. View

14.

Savin M, Mihailescu C, Matei I, Stan D, Moldovan C, Ion M . A quantum dot-based lateral flow immunoassay for the sensitive detection of human heart fatty acid binding protein (hFABP) in human serum. Talanta. 2017; 178:910-915. DOI: 10.1016/j.talanta.2017.10.045. View

15.

Kim S, Sung H, Hwang S, Kim M . A New Quantum Dot-Based Lateral Flow Immunoassay for the Rapid Detection of Influenza Viruses. Biochip J. 2022; 16(2):175-182. PMC: 8935104. DOI: 10.1007/s13206-022-00053-4. View

16.

Gupta Y, Ghrera A . Recent advances in gold nanoparticle-based lateral flow immunoassay for the detection of bacterial infection. Arch Microbiol. 2021; 203(7):3767-3784. DOI: 10.1007/s00203-021-02357-9. View

17.

Wang S, Liu Y, Jiao S, Zhao Y, Guo Y, Wang M . Quantum-Dot-Based Lateral Flow Immunoassay for Detection of Neonicotinoid Residues in Tea Leaves. J Agric Food Chem. 2017; 65(46):10107-10114. DOI: 10.1021/acs.jafc.7b03981. View

18.

Bauer M, Strom M, Hammond D, Shigdar S . Anything You Can Do, I Can Do Better: Can Aptamers Replace Antibodies in Clinical Diagnostic Applications?. Molecules. 2019; 24(23). PMC: 6930532. DOI: 10.3390/molecules24234377. View

19.

Mirica A, Stan D, Chelcea I, Mihailescu C, Ofiteru A, Bocancia-Mateescu L . Latest Trends in Lateral Flow Immunoassay (LFIA) Detection Labels and Conjugation Process. Front Bioeng Biotechnol. 2022; 10:922772. PMC: 9237331. DOI: 10.3389/fbioe.2022.922772. View

20.

Bruno J . Application of DNA Aptamers and Quantum Dots to Lateral Flow Test Strips for Detection of Foodborne Pathogens with Improved Sensitivity versus Colloidal Gold. Pathogens. 2014; 3(2):341-55. PMC: 4243449. DOI: 10.3390/pathogens3020341. View