Emetine in Combination with Chloroquine Induces Oncolytic Potential of HIV-1-Based Lentiviral Particles

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2022 Sep 23

PMID 36139404

Authors

Pavel Spirin

Elena Shyrokova

Valeria Vedernikova

Timofey Lebedev

Vladimir Prassolov

Affiliations

Soon will be listed here.

Abstract

Chloroquine and Emetine are drugs used to treat human parasitic infections. In addition, it has been shown that these drugs have an antiviral effect. Both drugs were also found to cause a suppressive effect on the growth of cancer cells of different origins. Here, using the replication-deficient HIV-1-based lentiviral vector particles, we evaluated the ability of the combination of these drugs to reduce viral transduction efficiency. We showed that these drugs act synergistically to decrease cancer cell growth when added in combination with medium containing lentiviral particles. We found that the combination of these drugs with lentiviral particles decreases the viability of treated cells. Taken together, we state the oncolytic potential of the medium containing HIV-1-based particles provoked by the combination of Chloroquine and Emetine.

Citing Articles

Nucleoside Analog 2',3'-Isopropylidene-5-Iodouridine as Novel Efficient Inhibitor of HIV-1.

Glumakova K, Ivanov G, Vedernikova V, Shyrokova L, Lebedev T, Stomakhin A Pharmaceutics. 2023; 15(10).

PMID: 37896149 PMC: 10610023. DOI: 10.3390/pharmaceutics15102389.

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