Emerging Roles of Ferroptosis in Cardiovascular Diseases

Overview

Journal Cell Death Discov

Date 2022 Sep 20

PMID 36127318

Authors

Kai Wang

Xin-Zhe Chen

Yun-Hong Wang

Xue-Li Cheng

Yan Zhao

Lu-Yu Zhou

Kun Wang

Affiliations

Soon will be listed here.

Abstract

The mechanism of cardiovascular diseases (CVDs) is complex and threatens human health. Cardiomyocyte death is an important participant in the pathophysiological basis of CVDs. Ferroptosis is a new type of iron-dependent programmed cell death caused by excessive accumulation of iron-dependent lipid peroxides and reactive oxygen species (ROS) and abnormal iron metabolism. Ferroptosis differs from other known cell death pathways, such as apoptosis, necrosis, necroptosis, autophagy and pyroptosis. Several compounds have been shown to induce or inhibit ferroptosis by regulating related key factors or signalling pathways. Recent studies have confirmed that ferroptosis is associated with the development of diverse CVDs and may be a potential therapeutic drug target for CVDs. In this review, we summarize the characteristics and related mechanisms of ferroptosis and focus on its role in CVDs, with the goal of inspiring novel treatment strategies.

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