Targeting Ferroptosis and Ferritinophagy: New Targets for Cardiovascular Diseases

Overview

Journal J Zhejiang Univ Sci B

Specialties Biology
General Medicine

Date 2024 Jan 1

PMID 38163663

Authors

Yi Luan

Yang Yang

Ying Luan

Hui Liu

Han Xing

Jinyan Pei

Hengdao Liu

Bo Qin

Kaidi Ren

Affiliations

Soon will be listed here.

Abstract

Cardiovascular diseases (CVDs) are a leading factor driving mortality worldwide. Iron, an essential trace mineral, is important in numerous biological processes, and its role in CVDs has raised broad discussion for decades. Iron-mediated cell death, namely ferroptosis, has attracted much attention due to its critical role in cardiomyocyte damage and CVDs. Furthermore, ferritinophagy is the upstream mechanism that induces ferroptosis, and is closely related to CVDs. This review aims to delineate the processes and mechanisms of ferroptosis and ferritinophagy, and the regulatory pathways and molecular targets involved in ferritinophagy, and to determine their roles in CVDs. Furthermore, we discuss the possibility of targeting ferritinophagy-induced ferroptosis modulators for treating CVDs. Collectively, this review offers some new insights into the pathology of CVDs and identifies possible therapeutic targets.

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