Adipose Tissue Macrophage in Obesity-associated Metabolic Diseases

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2022 Sep 19

PMID 36119080

Authors

Jingfei Yao

Dongmei Wu

Yifu Qiu

Affiliations

Soon will be listed here.

Abstract

Adipose tissue macrophage (ATM) has been appreciated for its critical contribution to obesity-associated metabolic diseases in recent years. Here, we discuss the regulation of ATM on both metabolic homeostatsis and dysfunction. In particular, the macrophage polarization and recruitment as well as the crosstalk between ATM and adipocyte in thermogenesis, obesity, insulin resistance and adipose tissue fibrosis have been reviewed. A better understanding of how ATM regulates adipose tissue remodeling may provide novel therapeutic strategies against obesity and associated metabolic diseases.

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