Emodin Modulates Gut Microbial Community and Triggers Intestinal Immunity

Overview

Journal J Sci Food Agric

Specialties Environmental Health
Nutritional Sciences

Date 2022 Sep 11

PMID 36088620

Authors

Humphrey A Mabwi

Hee Ju Lee

Emmanuel Hitayezu

Intan Rizki Mauliasari

Cheol-Ho Pan

Kilaza Samson Mwaikono

Erick V G Komba

Choong-Gu Lee

Kwang Hyun Cha

Affiliations

Soon will be listed here.

Abstract

Background: The gut microbiota (GM) plays an important role in human health and is being investigated as a possible target for new therapies. Although there are many studies showing that emodin can improve host health, emodin-GM studies are scarce. Here, the effects of emodin on the GM were investigated in vitro and in vivo.

Results: In vitro single bacteria cultivation showed that emodin stimulated the growth of beneficial bacteria Akkermansia, Clostridium, Roseburia, and Ruminococcus but inhibited major gut enterotypes (Bacteroides and Prevotella). Microbial community analysis from a synthetic gut microbiome model through co-culture indicated the consistent GM change by emodin. Interestingly, emodin stimulated Clostridium and Ruminococcus (which are related to Roseburia and Faecalibacterium) in a mice experiment and induced anti-inflammatory immune cells, which may correlate with its impact on specific gut bacteria.

Conclusion: Emodin (i) showed similar GM changes in monoculture, co-culture, and in an in vivo mice experiment and (ii) simulated regulatory T-cell immune responses in vivo. This suggest that emodin may be used to modulate the GM and improve health. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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