Contribution of Muscle Satellite Cells to Sarcopenia

Overview

Journal Front Physiol

Date 2022 Aug 29

PMID 36035464

Authors

Fengjiao Huo

Qing Liu

Hailiang Liu

Affiliations

Soon will be listed here.

Abstract

Sarcopenia, a disorder characterized by age-related muscle loss and reduced muscle strength, is associated with decreased individual independence and quality of life, as well as a high risk of death. Skeletal muscle houses a normally mitotically quiescent population of adult stem cells called muscle satellite cells (MuSCs) that are responsible for muscle maintenance, growth, repair, and regeneration throughout the life cycle. Patients with sarcopenia are often exhibit dysregulation of MuSCs homeostasis. In this review, we focus on the etiology, assessment, and treatment of sarcopenia. We also discuss phenotypic and regulatory mechanisms of MuSC quiescence, activation, and aging states, as well as the controversy between MuSC depletion and sarcopenia. Finally, we give a multi-dimensional treatment strategy for sarcopenia based on improving MuSC function.

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References

Revuelta M, Matheu A . Autophagy in stem cell aging. Aging Cell. 2017; 16(5):912-915. PMC: 5595672. DOI: 10.1111/acel.12655. View

Verdijk L, Dirks M, Snijders T, Prompers J, Beelen M, Jonkers R . Reduced satellite cell numbers with spinal cord injury and aging in humans. Med Sci Sports Exerc. 2012; 44(12):2322-30. DOI: 10.1249/MSS.0b013e3182667c2e. View

Lorenzo-Lopez L, Maseda A, de Labra C, Regueiro-Folgueira L, Rodriguez-Villamil J, Millan-Calenti J . Nutritional determinants of frailty in older adults: A systematic review. BMC Geriatr. 2017; 17(1):108. PMC: 5433026. DOI: 10.1186/s12877-017-0496-2. View

Wang J, Khodabukus A, Rao L, Vandusen K, Abutaleb N, Bursac N . Engineered skeletal muscles for disease modeling and drug discovery. Biomaterials. 2019; 221:119416. PMC: 7041662. DOI: 10.1016/j.biomaterials.2019.119416. View

Minetti G, Colussi C, Adami R, Serra C, Mozzetta C, Parente V . Functional and morphological recovery of dystrophic muscles in mice treated with deacetylase inhibitors. Nat Med. 2006; 12(10):1147-50. DOI: 10.1038/nm1479. View

Bi P, Ramirez-Martinez A, Li H, Cannavino J, McAnally J, Shelton J . Control of muscle formation by the fusogenic micropeptide myomixer. Science. 2017; 356(6335):323-327. PMC: 5502127. DOI: 10.1126/science.aam9361. View

Smeuninx B, Greig C, Breen L . Amount, Source and Pattern of Dietary Protein Intake Across the Adult Lifespan: A Cross-Sectional Study. Front Nutr. 2020; 7:25. PMC: 7086014. DOI: 10.3389/fnut.2020.00025. View

Picca A, Calvani R, Bossola M, Allocca E, Menghi A, Pesce V . Update on mitochondria and muscle aging: all wrong roads lead to sarcopenia. Biol Chem. 2018; 399(5):421-436. DOI: 10.1515/hsz-2017-0331. View

Churchward-Venne T, Pinckaers P, Smeets J, Peeters W, Zorenc A, Schierbeek H . Myofibrillar and Mitochondrial Protein Synthesis Rates Do Not Differ in Young Men Following the Ingestion of Carbohydrate with Whey, Soy, or Leucine-Enriched Soy Protein after Concurrent Resistance- and Endurance-Type Exercise. J Nutr. 2019; 149(2):210-220. PMC: 6561602. DOI: 10.1093/jn/nxy251. View

10.

Landi F, Marzetti E, Martone A, Bernabei R, Onder G . Exercise as a remedy for sarcopenia. Curr Opin Clin Nutr Metab Care. 2013; 17(1):25-31. DOI: 10.1097/MCO.0000000000000018. View

11.

Zhu H, Xiao F, Wang G, Wei X, Jiang L, Chen Y . STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. Cell Rep. 2016; 16(8):2102-2115. DOI: 10.1016/j.celrep.2016.07.041. View

12.

Tierney M, Aydogdu T, Sala D, Malecova B, Gatto S, Puri P . STAT3 signaling controls satellite cell expansion and skeletal muscle repair. Nat Med. 2014; 20(10):1182-6. PMC: 4332844. DOI: 10.1038/nm.3656. View

13.

Hawkins S, Marcell T, Jaque S, Wiswell R . A longitudinal assessment of change in VO2max and maximal heart rate in master athletes. Med Sci Sports Exerc. 2001; 33(10):1744-50. DOI: 10.1097/00005768-200110000-00020. View

14.

Zeng Z, Liang J, Wu L, Zhang H, Lv J, Chen N . Exercise-Induced Autophagy Suppresses Sarcopenia Through Akt/mTOR and Akt/FoxO3a Signal Pathways and AMPK-Mediated Mitochondrial Quality Control. Front Physiol. 2020; 11:583478. PMC: 7667253. DOI: 10.3389/fphys.2020.583478. View

15.

Gopinath S, Webb A, Brunet A, Rando T . FOXO3 promotes quiescence in adult muscle stem cells during the process of self-renewal. Stem Cell Reports. 2014; 2(4):414-26. PMC: 3986584. DOI: 10.1016/j.stemcr.2014.02.002. View

16.

Fry C, Lee J, Mula J, Kirby T, Jackson J, Liu F . Inducible depletion of satellite cells in adult, sedentary mice impairs muscle regenerative capacity without affecting sarcopenia. Nat Med. 2014; 21(1):76-80. PMC: 4289085. DOI: 10.1038/nm.3710. View

17.

Li H, Chen Q, Li C, Zhong R, Zhao Y, Zhang Q . Muscle-secreted granulocyte colony-stimulating factor functions as metabolic niche factor ameliorating loss of muscle stem cells in aged mice. EMBO J. 2019; 38(24):e102154. PMC: 6912059. DOI: 10.15252/embj.2019102154. View

18.

Bouillon K, Batty G, Hamer M, Sabia S, Shipley M, Britton A . Cardiovascular disease risk scores in identifying future frailty: the Whitehall II prospective cohort study. Heart. 2013; 99(10):737-42. PMC: 3632981. DOI: 10.1136/heartjnl-2012-302922. View

19.

Bjornson C, Cheung T, Liu L, Tripathi P, Steeper K, Rando T . Notch signaling is necessary to maintain quiescence in adult muscle stem cells. Stem Cells. 2011; 30(2):232-42. PMC: 3384696. DOI: 10.1002/stem.773. View

20.

Vinel C, Lukjanenko L, Batut A, Deleruyelle S, Pradere J, Le Gonidec S . The exerkine apelin reverses age-associated sarcopenia. Nat Med. 2018; 24(9):1360-1371. DOI: 10.1038/s41591-018-0131-6. View