Non-coding RNA in Rhabdomyosarcoma Progression and Metastasis

Overview

Journal Front Oncol

Specialty Oncology

Date 2022 Aug 29

PMID 36033507

Authors

Farah Ramadan

Raya Saab

Nader Hussein

Philippe Clezardin

Pascale A Cohen

Sandra E Ghayad

Affiliations

Soon will be listed here.

Abstract

Rhabdomyosarcoma (RMS) is a soft tissue sarcoma of skeletal muscle differentiation, with a predominant occurrence in children and adolescents. One of the major challenges facing treatment success is the presence of metastatic disease at the time of diagnosis, commonly associated with the more aggressive fusion-positive subtype. Non-coding RNA (ncRNA) can regulate gene transcription and translation, and their dysregulation has been associated with cancer development and progression. MicroRNA (miRNA) are short non-coding nucleic acid sequences involved in the regulation of gene expression that act by targeting messenger RNA (mRNA), and their aberrant expression has been associated with both RMS initiation and progression. Other ncRNA including long non-coding RNA (lncRNA), circular RNA (circRNA) and ribosomal RNA (rRNA) have also been associated with RMS revealing important mechanistic roles in RMS biology, but these studies are still limited and require further investigation. In this review, we discuss the established roles of ncRNA in RMS differentiation, growth and progression, highlighting their potential use in RMS prognosis, as therapeutic agents or as targets of treatment.

Citing Articles

The molecular conversations of sarcomas: exosomal non-coding RNAs in tumor's biology and their translational prospects.

Luongo M, Laurenziello P, Cesta G, Bochicchio A, Omer L, Falco G Mol Cancer. 2024; 23(1):172.

PMID: 39174949 PMC: 11340101. DOI: 10.1186/s12943-024-02083-y.

Transforming Growth Factor Beta and Alveolar Rhabdomyosarcoma: A Challenge of Tumor Differentiation and Chemotherapy Response.

Bhushan B, Iranpour R, Eshtiaghi A, da Silva Rosa S, Lindsey B, Gordon J Int J Mol Sci. 2024; 25(5).

PMID: 38474036 PMC: 10932473. DOI: 10.3390/ijms25052791.

MicroRNA-Mediated Regulation of Histone-Modifying Enzymes in Cancer: Mechanisms and Therapeutic Implications.

Szczepanek J, Tretyn A Biomolecules. 2023; 13(11).

PMID: 38002272 PMC: 10669115. DOI: 10.3390/biom13111590.

Genomic and Epigenetic Changes Drive Aberrant Skeletal Muscle Differentiation in Rhabdomyosarcoma.

Pomella S, Danielli S, Alaggio R, Breunis W, Hamed E, Selfe J Cancers (Basel). 2023; 15(10).

PMID: 37345159 PMC: 10216238. DOI: 10.3390/cancers15102823.

BET Bromodomain Degradation Disrupts Function but Not 3D Formation of RNA Pol2 Clusters.

Chin D, Osman I, Porch J, Kim H, Buck K, Rodriguez J Pharmaceuticals (Basel). 2023; 16(2).

PMID: 37259348 PMC: 9966215. DOI: 10.3390/ph16020199.

References

Miller I, Raposo G, Welsch U, Prazeres da Costa O, Thiel U, Lebar M . First identification of Ewing's sarcoma-derived extracellular vesicles and exploration of their biological and potential diagnostic implications. Biol Cell. 2013; 105(7):289-303. DOI: 10.1111/boc.201200086. View

Wang Y, Li M, Wang Y, Liu J, Zhang M, Fang X . A Zfp609 circular RNA regulates myoblast differentiation by sponging miR-194-5p. Int J Biol Macromol. 2018; 121:1308-1313. DOI: 10.1016/j.ijbiomac.2018.09.039. View

Hoye A, Couchman J, Wewer U, Fukami K, Yoneda A . The newcomer in the integrin family: integrin α9 in biology and cancer. Adv Biol Regul. 2012; 52(2):326-39. DOI: 10.1016/j.jbior.2012.03.004. View

Li L, Sarver A, Alamgir S, Subramanian S . Downregulation of microRNAs miR-1, -206 and -29 stabilizes PAX3 and CCND2 expression in rhabdomyosarcoma. Lab Invest. 2012; 92(4):571-83. DOI: 10.1038/labinvest.2012.10. View

Na Y, Kim J . Understanding cooperativity of microRNAs via microRNA association networks. BMC Genomics. 2014; 14 Suppl 5:S17. PMC: 3852507. DOI: 10.1186/1471-2164-14-S5-S17. View

Guo Z, Maki M, Ding R, Yang Y, Zhang B, Xiong L . Genome-wide survey of tissue-specific microRNA and transcription factor regulatory networks in 12 tissues. Sci Rep. 2014; 4:5150. PMC: 5381490. DOI: 10.1038/srep05150. View

Sun M, Li J, Guo L, Xiao H, Dong L, Wang F . TGF-β1 suppression of microRNA-450b-5p expression: a novel mechanism for blocking myogenic differentiation of rhabdomyosarcoma. Oncogene. 2013; 33(16):2075-86. DOI: 10.1038/onc.2013.165. View

Kara G, Calin G, Ozpolat B . RNAi-based therapeutics and tumor targeted delivery in cancer. Adv Drug Deliv Rev. 2022; 182:114113. DOI: 10.1016/j.addr.2022.114113. View

Lim L, Lau N, Garrett-Engele P, Grimson A, Schelter J, Castle J . Microarray analysis shows that some microRNAs downregulate large numbers of target mRNAs. Nature. 2005; 433(7027):769-73. DOI: 10.1038/nature03315. View

10.

Hanna J, Garcia M, Go J, Finkelstein D, Kodali K, Pagala V . PAX7 is a required target for microRNA-206-induced differentiation of fusion-negative rhabdomyosarcoma. Cell Death Dis. 2016; 7(6):e2256. PMC: 5143388. DOI: 10.1038/cddis.2016.159. View

11.

Wurdinger T, Costa F . Molecular therapy in the microRNA era. Pharmacogenomics J. 2006; 7(5):297-304. DOI: 10.1038/sj.tpj.6500429. View

12.

Skrzypek K, Kot M, Konieczny P, Nieszporek A, Kusienicka A, Lasota M . SNAIL Promotes Metastatic Behavior of Rhabdomyosarcoma by Increasing EZRIN and AKT Expression and Regulating MicroRNA Networks. Cancers (Basel). 2020; 12(7). PMC: 7408994. DOI: 10.3390/cancers12071870. View

13.

Rao P, Kumar R, Farkhondeh M, Baskerville S, Lodish H . Myogenic factors that regulate expression of muscle-specific microRNAs. Proc Natl Acad Sci U S A. 2006; 103(23):8721-6. PMC: 1482645. DOI: 10.1073/pnas.0602831103. View

14.

Jin J, Lv W, Xia P, Xu Z, Zheng A, Wang X . Long noncoding RNA regulates myogenesis by interacting with polycomb repressive complex 2. Proc Natl Acad Sci U S A. 2018; 115(42):E9802-E9811. PMC: 6196504. DOI: 10.1073/pnas.1801471115. View

15.

Sun L, Liu L, Yang X, Wu Z . Akt binds prohibitin 2 and relieves its repression of MyoD and muscle differentiation. J Cell Sci. 2004; 117(Pt 14):3021-9. DOI: 10.1242/jcs.01142. View

16.

Dykes I, Emanueli C . Transcriptional and Post-transcriptional Gene Regulation by Long Non-coding RNA. Genomics Proteomics Bioinformatics. 2017; 15(3):177-186. PMC: 5487525. DOI: 10.1016/j.gpb.2016.12.005. View

17.

Ghamloush F, Ghayad S, Rammal G, Fahs A, Ayoub A, Merabi Z . The PAX3-FOXO1 oncogene alters exosome miRNA content and leads to paracrine effects mediated by exosomal miR-486. Sci Rep. 2019; 9(1):14242. PMC: 6775163. DOI: 10.1038/s41598-019-50592-4. View

18.

Babae N, Bourajjaj M, Liu Y, van Beijnum J, Cerisoli F, Scaria P . Systemic miRNA-7 delivery inhibits tumor angiogenesis and growth in murine xenograft glioblastoma. Oncotarget. 2014; 5(16):6687-700. PMC: 4196156. DOI: 10.18632/oncotarget.2235. View

19.

Hanna J, Hossain G, Kocerha J . The Potential for microRNA Therapeutics and Clinical Research. Front Genet. 2019; 10:478. PMC: 6532434. DOI: 10.3389/fgene.2019.00478. View

20.

Frose J, Chen M, Hebron K, Reinhardt F, Hajal C, Zijlstra A . Epithelial-Mesenchymal Transition Induces Podocalyxin to Promote Extravasation via Ezrin Signaling. Cell Rep. 2018; 24(4):962-972. PMC: 6181240. DOI: 10.1016/j.celrep.2018.06.092. View