Caucasian Dragonheads: Phenolic Compounds, Polysaccharides, and Bioactivity of and

Overview

Journal Plants (Basel)

Date 2022 Aug 26

PMID 36015428

Authors

Nina I Kashchenko

Gunay S Jafarova

Javanshir I Isaev

Daniil N Olennikov

Nadezhda K Chirikova

Affiliations

Soon will be listed here.

Abstract

Steven and L. are unexplored species of the genus (Lamiaceae family) with a distribution in the Caucasus, where they are used in folk medicine and local cuisine. There are no data on the chemical composition of these species. In this study, the application of a liquid chromatography-mass spectrometry technique for the metabolite profiling of methanol extracts from herbs and roots of and resulted in the identification of 50 compounds, including benzoic acid derivatives, phenylpropanoids, flavonoids and lignans. Water-soluble polysaccharides of the herbs and roots of and were isolated and characterized as mostly pectins with additive arabinogalactan-protein complexes and starch-like compounds. The antioxidant potential of the studied extracts of and selected phenolics and water-soluble polysaccharides were investigated via radical-scavenging and ferrous (II) ion chelating assays. This paper demonstrates that herbs and roots of and are rich sources of metabolites and could be valuable plants for new biologically active products. To the best of our knowledge, this is the first study of whole plant metabolites and their antioxidant activity in and .

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References

Li Q, Liu Y, Han L, Liu J, Liu W, Feng F . Chemical constituents and quality control of two Dracocephalum species based on high-performance liquid chromatographic fingerprints coupled with tandem mass spectrometry and chemometrics. J Sep Sci. 2016; 39(21):4071-4085. DOI: 10.1002/jssc.201600645. View

Wang S, Han X, Li X, Ren D, Wang X, Lou H . Flavonoids from Dracocephalum tanguticum and their cardioprotective effects against doxorubicin-induced toxicity in H9c2 cells. Bioorg Med Chem Lett. 2010; 20(22):6411-5. DOI: 10.1016/j.bmcl.2010.09.086. View

Sieminska-Kuczer A, Szymanska-Chargot M, Zdunek A . Recent advances in interactions between polyphenols and plant cell wall polysaccharides as studied using an adsorption technique. Food Chem. 2021; 373(Pt B):131487. DOI: 10.1016/j.foodchem.2021.131487. View

Lakey-Beitia J, Burillo A, La Penna G, Hegde M, Rao K . Polyphenols as Potential Metal Chelation Compounds Against Alzheimer's Disease. J Alzheimers Dis. 2020; 82(s1):S335-S357. PMC: 7809605. DOI: 10.3233/JAD-200185. View

Sadraei H, Asghari G, Khanabadi M, Minaiyan M . Anti-inflammatory effect of apigenin and hydroalcoholic extract of on acetic acid-induced colitis in rats. Res Pharm Sci. 2017; 12(4):322-329. PMC: 5566007. DOI: 10.4103/1735-5362.212050. View

Olennikov D, Chirikova N, Kashchenko N, Gornostai T, Selyutina I, Zilfikarov I . Effect of Low Temperature Cultivation on the Phytochemical Profile and Bioactivity of Arctic Plants: A Case of Dracocephalum palmatum. Int J Mol Sci. 2017; 18(12). PMC: 5751182. DOI: 10.3390/ijms18122579. View

Zeng Q, Jin H, Qin J, Fu J, Hu X, Liu J . Chemical constituents of plants from the genus Dracocephalum. Chem Biodivers. 2010; 7(8):1911-29. DOI: 10.1002/cbdv.200900188. View

Hu Z, Wang J, Jin L, Duan Y, Zhang X, Sun J . Isolation and Structural Characterization of Two Polysaccharides from Dracocephalum moldavica and Their Anti-Complementary Activity. Chem Biodivers. 2022; 19(7):e202200294. DOI: 10.1002/cbdv.202200294. View

Saeidnia S, Gohari A, Ito M, Kiuchi F, Honda G . Bioactive constituents from Dracocephalum subcapitatum (O. Kuntze) Lipsky. Z Naturforsch C J Biosci. 2005; 60(1-2):22-4. DOI: 10.1515/znc-2005-1-204. View

10.

Mnich E, Bjarnholt N, Eudes A, Harholt J, Holland C, JOrgensen B . Phenolic cross-links: building and de-constructing the plant cell wall. Nat Prod Rep. 2020; 37(7):919-961. DOI: 10.1039/c9np00028c. View

11.

Yang X, Liu Y, Chen T, Wang N, Li H, Zhao J . HSCCC Separation of Three Main Compounds from the Crude Extract of Dracocephalum Tanguticum by Using Dimethyl Sulfoxide as Cosolvent. J Chromatogr Sci. 2020; 59(2):175-181. DOI: 10.1093/chromsci/bmaa094. View

12.

Olennikov D, Chirikova N, Okhlopkova Z, Zulfugarov I . Chemical composition and antioxidant activity of Tánara Ótó (Dracocephalum palmatum Stephan), a medicinal plant used by the North-Yakutian nomads. Molecules. 2013; 18(11):14105-21. PMC: 6269879. DOI: 10.3390/molecules181114105. View

13.

Gu H, Chen R, Sun Y, Liu F . [Studies on chemical constituents from herb of Dracocephalum moldavica]. Zhongguo Zhong Yao Za Zhi. 2005; 29(3):232-4. View

14.

Stappen I, Wanner J, Tabanca N, Wedge D, Ali A, Kaul V . Chemical composition and biological activity of essential oils of Dracocephalum heterophyllum and Hyssopus officinalis from Western Himalaya. Nat Prod Commun. 2015; 10(1):133-8. View

15.

Olennikov D, Kashchenko N, Chirikova N . A novel HPLC-assisted method for investigation of the Fe2+-chelating activity of flavonoids and plant extracts. Molecules. 2014; 19(11):18296-316. PMC: 6270772. DOI: 10.3390/molecules191118296. View

16.

Heydari P, Yavari M, Adibi P, Asghari G, Ghanadian S, Dida G . Medicinal Properties and Active Constituents of and Its Significance in Iran: A Systematic Review. Evid Based Complement Alternat Med. 2019; 2019:9465309. PMC: 6526565. DOI: 10.1155/2019/9465309. View

17.

Masuda T, Fujita N, Odaka Y, Takeda Y, Yonemori S, Nakamoto K . Tyrosinase inhibitory activity of ethanol extracts from medicinal and edible plants cultivated in okinawa and identification of a water-soluble inhibitor from the leaves of Nandina domestica. Biosci Biotechnol Biochem. 2007; 71(9):2316-20. DOI: 10.1271/bbb.70249. View

18.

Olennikov D, Chirikova N, Vasilieva A, Fedorov I . LC-MS Profile, Gastrointestinal and Gut Microbiota Stability and Antioxidant Activity of Herb Metabolites: A Comparative Study with Subterranean Organs. Antioxidants (Basel). 2020; 9(6). PMC: 7346138. DOI: 10.3390/antiox9060526. View

19.

Guo Z, Liang X, Xie Y . Qualitative and quantitative analysis on the chemical constituents in Orthosiphon stamineus Benth. using ultra high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. J Pharm Biomed Anal. 2018; 164:135-147. DOI: 10.1016/j.jpba.2018.10.023. View

20.

Yeung A, Heinrich M, Atanasov A . Ethnopharmacology-A Bibliometric Analysis of a Field of Research Meandering Between Medicine and Food Science?. Front Pharmacol. 2018; 9:215. PMC: 5862826. DOI: 10.3389/fphar.2018.00215. View