The Insulin-like Growth Factor System and Colorectal Cancer

Overview

Journal Life (Basel)

Specialty Biology

Date 2022 Aug 26

PMID 36013453

Authors

Nikola Gligorijevic

Zorana Dobrijevic

Milos Sunderic

Dragana Robajac

Danilo cetic

Ana Penezic

Goran Miljus

Olgica Nedic

Affiliations

Soon will be listed here.

Abstract

Insulin-like growth factors (IGFs) are peptides which exert mitogenic, endocrine and cytokine activities. Together with their receptors, binding proteins and associated molecules, they participate in numerous pathophysiological processes, including cancer development. Colorectal cancer (CRC) is a disease with high incidence and mortality rates worldwide, whose etiology usually represents a combination of the environmental and genetic factors. IGFs are most often increased in CRC, enabling excessive autocrine/paracrine stimulation of the cell growth. Overexpression or increased activation/accessibility of IGF receptors is a coinciding step which transmits IGF-related signals. A number of molecules and biochemical mechanisms exert modulatory effects shaping the final outcome of the IGF-stimulated processes, frequently leading to neoplastic transformation in the case of irreparable disbalance. The IGF system and related molecules and pathways which participate in the development of CRC are the focus of this review.

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