LncRNAs Involved in Antioxidant Response Regulation As Biomarkers of Gestational Diabetes: A Study on , and

Recent findings highlighted the potential of long non-coding RNAs (lncRNAs) as novel indicators of gestational diabetes mellitus (GDM), as they demonstrate altered expression in metabolic disorders, oxidative stress (OS) and inflammation (IFM). The aim of this study was to evaluate the diagnostic potential and prognostic significance of the OS/IFM-related lncRNAs H19, and in GDM and their correlations with redox status-related parameters. The relative quantification of selected lncRNAs from peripheral blood mononuclear cells (PBMCs) of GDM patients and controls (n = 50 each) was performed by qPCR. The expression levels were tested for correlations with metal ion concentrations, NRF2 expression, activities of glutathione reductase (GR), superoxide dismutase (SOD), catalase (CAT), serum thiol content, protein carbonyl level and thiobarbituric acid reactive substances. and were significantly downregulated in GDM patients ( = 0.0095 and = 0.012, respectively). A correlation was observed between expression and zinc levels in both GDM patients and controls. expression positively correlated with levels in GDM patients ( = 0.026), while exhibited a positive correlation with GR activity in controls ( = 0.018) and an inverse correlation with SOD activity ( = 0.048). Our data show the disturbance of OS/IFM-lncRNAs in GDM pathogenesis and illustrate the biomarker potential of the analyzed lncRNAs, as well as of certain redox status parameters.