Magnetic-Responsive Doxorubicin-Containing Materials Based on FeO Nanoparticles with a SiO/PEG Shell and Study of Their Effects on Cancer Cell Lines

Overview

Journal Int J Mol Sci

Publisher MDPI

Specialties Biochemistry
Chemistry
Molecular Biology

Date 2022 Aug 26

PMID 36012356

Authors

Alexander M Demin

Alexander V Vakhrushev

Alexandra G Pershina

Marina S Valova

Lina V Efimova

Alexandra A Syomchina

Mikhail A Uimin

Artem S Minin

Galina L Levit

Victor P Krasnov

Valery N Charushin

Affiliations

Soon will be listed here.

Abstract

Novel nanocomposite materials based on FeO magnetic nanoparticles (MNPs) coated with silica and covalently modified by [(3-triethoxysilyl)propyl]succinic acid-polyethylene glycol (PEG 3000) conjugate, which provides a high level of doxorubicin (Dox) loading, were obtained. The efficiency of Dox desorption from the surface of nanomaterials under the action of an alternating magnetic field (AMF) in acidic and neutral media was evaluated. Their high cytotoxicity against tumor cells, as well as the drug release upon application of AMF, which leads to an increase in the cytotoxic effect, was demonstrated.

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