Unraveling the Complexity of Liver Disease One Cell at a Time

Overview

Journal Semin Liver Dis

Publisher Thieme

Specialty Gastroenterology

Date 2022 Aug 25

PMID 36008091

Authors

Jawairia Atif

Cornelia Thoeni

Gary D Bader

Ian D McGilvray

Sonya A MacParland

Affiliations

Soon will be listed here.

Abstract

The human liver is a complex organ made up of multiple specialized cell types that carry out key physiological functions. An incomplete understanding of liver biology limits our ability to develop therapeutics to prevent chronic liver diseases, liver cancers, and death as a result of organ failure. Recently, single-cell modalities have expanded our understanding of the cellular phenotypic heterogeneity and intercellular cross-talk in liver health and disease. This review summarizes these findings and looks forward to highlighting new avenues for the application of single-cell genomics to unravel unknown pathogenic pathways and disease mechanisms for the development of new therapeutics targeting liver pathology. As these technologies mature, their integration into clinical data analysis will aid in patient stratification and in developing treatment plans for patients suffering from liver disease.

Citing Articles

Liver in infections: a single-cell and spatial transcriptomics perspective.

Zou J, Li J, Zhong X, Tang D, Fan X, Chen R J Biomed Sci. 2023; 30(1):53.

PMID: 37430371 PMC: 10332047. DOI: 10.1186/s12929-023-00945-z.

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