Chromatin Structure of the HLA-DR Alpha Gene in Different Functional States of Major Histocompatibility Complex Class II Gene Expression

Overview

Journal Mol Cell Biol

Specialty Cell Biology

Date 1987 May 1

PMID 3600654

Citations 8

Authors

B M Peterlin

K J Hardy

A S Larsen

Affiliations

Soon will be listed here.

Abstract

We utilized DNase I hypersensitivity mapping to study chromatin structure within the HLA-DR alpha gene. We found a single DNase I-hypersensitive site coinciding with the HLA-DR alpha gene promoter in all cells studied. Moreover, in cells that constitutively express HLA-DR, two additional DNase I-hypersensitive sites were observed. These lie within the first intron of the HLA-DR alpha gene and encompass DNA sequences that share homologies with regulatory loci of the immunoglobulin and immune response genes, as well as with core enhancer consensus sequences.

Citing Articles

B-cell-specific and interferon-gamma-inducible regulation of the HLA-DR alpha gene.

Tsang S, Nakanishi M, Peterlin B Proc Natl Acad Sci U S A. 1988; 85(22):8598-602.

PMID: 3141929 PMC: 282506. DOI: 10.1073/pnas.85.22.8598.

Transcriptional enhancers in the HLA-DQ subregion.

Sullivan K, Peterlin B Mol Cell Biol. 1987; 7(9):3315-9.

PMID: 3118196 PMC: 367969. DOI: 10.1128/mcb.7.9.3315-3319.1987.

Structure of a mouse erythroid 5-aminolevulinate synthase gene and mapping of erythroid-specific DNAse I hypersensitive sites.

Schoenhaut D, Curtis P Nucleic Acids Res. 1989; 17(17):7013-28.

PMID: 2780318 PMC: 318430. DOI: 10.1093/nar/17.17.7013.

A rabbit class II MHC gene with strong similarities to HLA-DRA.

Laverriere A, Kulaga H, Kindt T, LeGuern C, Marche P Immunogenetics. 1989; 30(2):137-40.

PMID: 2759665 DOI: 10.1007/BF02421545.

Hypomethylation of the human HLA-DR alpha gene in breast carcinomas and autologous metastases.

Barbieri R, Rimondi A, Buzzoni D, LUPPI L, Nastruzzi C, Orlando P Clin Exp Metastasis. 1989; 7(4):417-26.

PMID: 2706829 DOI: 10.1007/BF01753662.

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