Subversion of Autophagy Machinery and Organelle-specific Autophagy by SARS-CoV-2 and Coronaviruses

Overview

Journal Autophagy

Specialty Cell Biology

Date 2022 Aug 25

PMID 36005882

Authors

Qinqin Sun

Xiaojuan Li

Ersheng Kuang

Affiliations

Soon will be listed here.

Abstract

As a new emerging severe coronavirus, the knowledge on the SARS-CoV-2 and COVID-19 remains very limited, whereas many concepts can be learned from the homologous coronaviruses. Macroautophagy/autophagy is finely regulated by SARS-CoV-2 infection and plays important roles in SARS-CoV-2 infection and pathogenesis. This review will explore the subversion and mechanism of the autophagy-related machinery, vacuoles and organelle-specific autophagy during infection of SARS-CoV-2 and coronaviruses to provide meaningful insights into the autophagy-related therapeutic strategies for infectious diseases of SARS-CoV-2 and coronaviruses.

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