Research Progress on the Synthesis and Pharmacology of 1,3,4-oxadiazole and 1,2,4-oxadiazole Derivatives: a Mini Review

Overview

Journal J Enzyme Inhib Med Chem

Specialty Biochemistry

Date 2022 Aug 24

PMID 36000176

Authors

Jing-Jing Wang

Wen Sun

Wei-Dong Jia

Ming Bian

Li-Jun Yu

Affiliations

Soon will be listed here.

Abstract

Oxadiazole is a five-membered heterocyclic compound containing two nitrogen atoms and one oxygen atom. The 1,3,4-oxadiazole and 1,2,4-oxadiazole have favourable physical, chemical, and pharmacokinetic properties, which significantly increase their pharmacological activity hydrogen bond interactions with biomacromolecules. In recent years, oxadiazole has been demonstrated to be the biologically active unit in a number of compounds. Oxadiazole derivatives exhibit antibacterial, anti-inflammatory, anti-tuberculous, anti-fungal, anti-diabetic and anticancer activities. In this paper, we report a series of compounds containing oxadiazole rings that have been published in the last three years only (2020-2022) as there was no report or their activities described in any article in 2019, which will be useful to scientists in research fields of organic synthesis, medicinal chemistry, and pharmacology.

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